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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 132 - 137 (6page)
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초록· 키워드
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Purpose :
The purpose of this study was to evaluate the role of immediate postoperative radiotherapy (RT) in adult patients with a low-grade oligodendroglioma (LODG).
Materials and Methods :
A total of 74 patients, older than 15 years, were treated in our institution between April 1990 and March 2006 for newly diagnosed LODGs. After surgery, 43 patients were treated with immediate RT with a total dose of 54~55.8 Gy with 1.8 Gy fractions (RT group) and 31 patients were followed with no adjuvant RT (OP group). All patients were closely observed until tumor progression or death with frequent work-ups including neurological examinations and MRI. Primary endpoints were overall survival and progression-free survival. The median follow-up duration of survivors was 6.2 years in the RT group and 5.8 years in the OP group.
Results :
Median progression-free survival was 13.2 years in the RT group and 4.6 years in the OP group; multivariate analysis confirmed improved outcome with the use of immediate RT (hazard ratio, 0.22; 95% confidence interval-CI, 0.090.55; p＜0.001). Median overall survival was 14.9 years in the RT group and 9.8 years in the OP group; the use of adjuvant RT was also associated with a trend toward better overall survival after immediate RT based on multivariate analysis (hazard ratio, 0.3; 95% CI, 0.08~1.17; p=0.082). No severe RT related complications were observed.
Conclusion :
Immediate RT following surgery appears to be an effective treatment modality for supratentorial LODGs. However, the potential benefit of adjuvant RT for overall survival needs to be tested prospectively in the future.
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참고문헌 (23)
참고문헌 신청
Allam A / 2000 / Oligodendroglioma: an analysis of prognostic factors and treatment results / Am J Clin Oncol 23 : 170 ~ 175
Bauman G / 1999 / Low grade glioma: a measuring radiographic response to radiotherapy / Can J Neurol Sci 26 : 18 ~ 22
Berrino F / 2003 / The EUROCARE Study: strengths, limitations and perspectives of population-based, comparative survival studies / Ann Oncol 14 : S9 ~ 13
CBTRUS / 2004 / Primary brain tumors in the united states. Statistical Report 1997-2001
Celli P / 1994 / Cerebral oligodendroglioma: prognostic factors and life history / Neurosurgery 35 : 1018 ~ 1034
Bauman G / 1999 / Low grade glioma: a measuring radiographic response to radiotherapy / Can J Neurol Sci 26 : 18 ~ 22
Berrino F / 2003 / The EUROCARE Study: strengths, limitations and perspectives of population-based, comparative survival studies / Ann Oncol 14 : S9 ~ 13
CBTRUS / 2004 / Primary brain tumors in the united states. Statistical Report 1997-2001
Celli P / 1994 / Cerebral oligodendroglioma: prognostic factors and life history / Neurosurgery 35 : 1018 ~ 1034
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