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논문 기본 정보

자료유형
학술저널
저자정보
저널정보
대한암학회 Cancer Research and Treatment Cancer Research and Treatment 제40권 제4호
발행연도
2008.1
수록면
164 - 171 (8page)

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Purpose: Retinoblastoma is the most common intraocular malignancy in children. Since the 1990s, chemotherapy was indicated for intraocluar disease to reduce the frequency of enucleation and spare the complications associated with external beam radiation. In this study, we analyzed treatment results of retinoblastoma in our institute. Materials and Methods: Datas from children diagnosed with retinoblastoma and treated at Seoul National University Children’s Hospital between 1986 and 2008 were analyzed retrospectively. We utilized cyclophosphamide, vincristine, adriamycin, and methotrexate (CVAM) for OPD-based adjuvant chemotherapy. From 1990, primary chemotherapy was administered to patients with intraocular disease for eyeball-saving and patients received a combination of etoposide, vincristine, cisplatin (or ifosfamide) as a moderately intensive regimen, or a combination of cisplatin, doxorubicin, etoposide, and cycophosphamide (CDEC) as a highly intensive regimen. Results: One hundred eighteen children were analyzed. There were 68 unilateral and 50 bilateral diseases. The median age at diagnosis was 1 year and ReeseEllsworth stage V was the most common stage at the time of diagnosis. All patients were treated by chemotherapy-based multimodality methods, and primary chemotherapy was administered to 80 patients. The 10-year overall and event-free survival rate of all patients were 93.9% and 91.6%, respectively. Two patients who died were in the CDEC regimen group, but there was no significant statistical difference in survival rates by chemotherapy regimens. Fifty-six of 114 eyeballs were saved after primary chemotherapy-based treatment, and the eyeball-saving rate was 49.1%. Six patients relapsed after enucleation and 2 patients were treated successfully after autologous PBSCT. Osteosarcoma occurred in 2 patients as a secondary malignancy, and facial asymmetry after radiotherapy was the most common long-term sequelae. Conclusions: In this study, the overall and event-free survival rates of retinoblastoma were satisfactory and eye-saving was possible with primary chemotherapy. Development of new chemotherapeutic regimens and a team approach are necessary to improve the eyeball-saving rate.
#Retinoblastoma #Chemotherapy #Radiotherapy #Enucleation #Survival rate #Eyeball-saving

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참고문헌 (21)

참고문헌 신청
Abramson DH / 1994 / Servodidio CA.Changing trends in the management of retinoblastoma: 1951-1965 vs 1966-1980 / J Pediatr Ophthalmol Strabismus 31 : 32 ~ google schola Akiyama K. / 1989 / Chemotherapyfor retinoblastoma / Ophthalmic Paediatr Genet 10 : 111 ~ 116 google schola Campinchi R. / 1976 / Does chemotherapy have a rolein the treatment of retinoblastomas / BullSoc Ophtalmol 76 : 17 ~ 22 google schola Chintagumpala M. / 2007 / Paysse EA, Plon SE,Hurwitz R. Retinoblastoma: review of current management / Oncologist 12 : 1237 ~ 1246 google schola De Potter P. / 2002 / Current treatment of retinoblastoma / Curr OpinOphthalmol 13 : 331 ~ 6 google schola

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