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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 172 - 177 (6page)
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초록· 키워드
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Purpose: In this study, we investigated the clinical characteristics and treatment results of osteosarcoma during the past 7 years, and evaluated the role of high dose chemotherapy (HDCT) with autologous stem cell transplantation (ASCT).
Materials and Methods: We retrospectively analyzed the clinical data of patients who were diagnosed as osteosarcoma at our center from January, 2000 to December, 2007.
Results: The 5-year overall survival and event-free survival of the patients were 72.6% and 55.9%, respectively. Seventeen (41.5%) patients showed disease progression during treatment or relapse after the end of treatment. The patients who had metastasis at diagnosis or who had a lower grade of necrosis after neoadjuvant chemotherapy showed decreased overall and event-free survival. Four patients received ASCT after HDCT, and 3 of them are alive without disease.
Conclusions: The patients who relapsed or had refractory osteosarcoma or who had metastasis at diagnosis or a lower grade of necrosis after neoadjuvant chemotherapy showed poor prognosis. HDCT with ASCT could be an alternative treatment option for these patients.
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등록된 정보가 없습니다.
참고문헌 (14)
참고문헌 신청
Bacci G. / 1990 / Primary chemotherapy and delayed surgery (neoadjuvantchemotherapy) for osteosarcoma of the extremities / TheIstituto Rizzoli Experience in 127 patients trea
Bacci G. / 1993 / Primary chemotherapy and delayed surgery for nonmetastaticosteosarcoma of the extremities / Results in 164patients preoperatively treated with high doses of
Bielack SS / 1993 / Intraarterialchemotherapy for osteosarcoma: does the result really justifythe effort / Cancer Treat Res 62 : 85 ~ 92
Bielack SS / 2002 / Prognostic factors in high-grade osteosarcomaof the extremities or trunk: an analysis of 1,702 patients treatedon neoadjuvant cooperative osteosarcoma stu
Choi HS / 1998 / Treatment Result of Pediatric Osteosarcoma withIntraarterial Cisplatin / J Korean Cancer Assoc 30 : 169 ~ 177
Bacci G. / 1993 / Primary chemotherapy and delayed surgery for nonmetastaticosteosarcoma of the extremities / Results in 164patients preoperatively treated with high doses of
Bielack SS / 1993 / Intraarterialchemotherapy for osteosarcoma: does the result really justifythe effort / Cancer Treat Res 62 : 85 ~ 92
Bielack SS / 2002 / Prognostic factors in high-grade osteosarcomaof the extremities or trunk: an analysis of 1,702 patients treatedon neoadjuvant cooperative osteosarcoma stu
Choi HS / 1998 / Treatment Result of Pediatric Osteosarcoma withIntraarterial Cisplatin / J Korean Cancer Assoc 30 : 169 ~ 177
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