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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.1
- 수록면
- 183 - 190 (8page)
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Purpose: To reveal the interaction between β-Lapachone (β-lap) and ionizing radiation in causing cell death in RKO human colon adenocarcinoma cells, and to elucidate the potential usefulness of combined β-lap treatment and radiotherapy for cancer treatment.
Materials and Methods: The cytotoxicities of various treatments were determined in vitro using clonogenic and apoptotic cell death. The changes in cell cycle distribution were studied using flow cytometry and an in vitro kinase assay. The tumor growth was studied using RKO tumors grown s.c. in the hind leg BALB/c- nuslc nude mice.
Results: β-lap caused clonogenic cell death and rapid apoptosis in RKO cells in vitro, in a dose dependent manner. The repair of sublethal radiation damage was almost completely inhibited when cells were maintained in β-lap during the interval between the two-dose irradiation. Flow cytometry study demonstrated that β-lap induced apoptosis, independent of the cell cycle phase, and completely prohibited the induction of radiationinduced G2 arrest in irradiated cells. The prohibition of radiation-induced G2 arrest is unclear, but may be related to the profound suppression of the p53, p21 and cyclin B1-Cdc2 kinase activities observed in cells treated with β-lap. The combination of β-lap and radiation markedly enhanced the radiation-induced growth suppression of tumors.
Conclusion: β-lap is cytotoxic against RKO cells, both in vitro and in vivo, and also sensitized cells to ionizing radiation by inhibiting sublethal radiation damage repair. β-lap is potentially useful as a potent anti-cancer chemotherapy drug and potent radiosensitizer against caner cells
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참고문헌 (25)
참고문헌 신청
/ 1984 / Beta-Lapachone greatly enhancesMMS lethality to human fibroblasts 118 : 828 ~ 34
/ 1987 / Potentiation of halogenatedpyrimidine radiosensitizers in human carcinoma cells bybeta-lapachone : 4 2 2 6 5361 ~ 6
/ 1989 / Inhibition of potentiallylethal DNA damage repair in human tumor cells by betalapachone an activator of topoisomerase I 49 : 605 ~ 12
/ 1989 / Inhibition or radiation-induced neoplastictransformation by beta-lapachone 86 : 4963 ~ 7
/ 1993 / Isolation ofX-ray-inducible transcripts from radioresistant melanoma cells 90 : 7200 ~ 4
/ 1987 / Potentiation of halogenatedpyrimidine radiosensitizers in human carcinoma cells bybeta-lapachone : 4 2 2 6 5361 ~ 6
/ 1989 / Inhibition of potentiallylethal DNA damage repair in human tumor cells by betalapachone an activator of topoisomerase I 49 : 605 ~ 12
/ 1989 / Inhibition or radiation-induced neoplastictransformation by beta-lapachone 86 : 4963 ~ 7
/ 1993 / Isolation ofX-ray-inducible transcripts from radioresistant melanoma cells 90 : 7200 ~ 4
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