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자료유형
학술저널
저자정보
Khan, Z.N. (Department of Biosciences, COMSATS Institute of Information Technology [CIIT]) Sabir, M. (Department of Biosciences, COMSATS Institute of Information Technology [CIIT]) Kayani, M.A. (Department of Biosciences, COMSATS Institute of Information Technology [CIIT]) Saeed, M. (Department of Biosciences, COMSATS Institute of Information Technology [CIIT])
저널정보
아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제14권 제4호
발행연도
2013.1
수록면
2,255 - 2,258 (4page)

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The activity of Rb proteins is controlled by post-translational modifications, especially through phosphorylation. Acetylation of Rb2/p130 was reported recently in NIH3T3 cells but its physiological relevance in cell cycle control and tumorigenesis is still unknown. Efforts are underway to investigate possible interplay between Rb2/p130 phosphorylation and acetylation. Here we hypothesized that Rb2/p130 acetylation, like p53 acetylation, may play a role in development of the tumor phenotype. The proposed hypothesis regarding acetylation of Rb2/p130 in tumor VS normal cells was found to be true in our case study of 36 tumor samples. Statistical analysis of results suggest strong correlation among Rb2/p130 acetylation and cancer phenotype.

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