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학술저널
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대한암학회 Cancer Research and Treatment Cancer Research and Treatment 제39권 제1호
발행연도
2007.1
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1 - 5 (5page)

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Purpose: Although concurrent chemoradiotherapy (CCRT) has been considered as a standard treatment for locally advanced squamous cell carcinoma of the head and neck (SCCHN), this treament is associated with increased toxicities such as mucositis and dermatitis. As a result, the dose intensity can be reduced and interruptions of radiotherapy are more common for CCRT than for sequential treatment, especially for the elderly patients. This prospective study was performed to assess the efficacy and safety profiles of the induction chemotherapy of docetaxel and cisplatin for elderly patients with locally advanced SCCHN. Materials and Methods: Patients over 65 years of age with locally advanced SCCHN were treated with docetaxel (70 mg/m2) and cisplatin (75 mg/m2) every 21 days. The chemotherapy consisted of two cycles with a third cycle that was administered to the responding patients. Patients who did not respond to initial chemotherapy underwent radiotherapy as a definitive local treatment. Results: Fifty patients were enrolled in this study and 44 patients were assessable for response and toxicity. The overall response rate was 88%, 16 patients (36%) achieved a complete response and 23 patients (52%) achieved a partial response. After a median follow-up of 24 months (range: 9～38 months) the median disease free period and overall survival period had not yet been reached. The one year and two year survival rates were 89% and 70%, respectively. The most common grade 3/4 adverse event was neutropenia, which occurred in 33 patients (75%) and 4 patients had febrile neutropenia. Conclusion: Combination chemotherapy of docetaxel and cisplatin is an effective regimen with an acceptable safety profile as the induction treatment for elderly patients suffering with SCCHN. (Cancer Res Treat. 2007; 39:1-5)
#Docetaxel #Cisplatin #Head and neck cancer #Induction chemtherapy

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참고문헌 (19)

참고문헌 신청
Browman GP / 1994 / Evidence-based recommendations against neoadjuvant chemotherapy for routine management of patients with squamous cell head and neck cancer 12 : 662 ~ 70 google schola Busse PM / 1998 / Induction chemotherapy with docetaxel and leucovorin for squamous cell carcinoma of the head and neck : 1331 ~ 9 google schola Dreyfuss AI / 1996 / Docetaxel:an active drug for squamous cell carcinoma of the head and neck 14 : 1672 ~ 8 google schola Ensley JF / 1984 / Correlation between response to cisplatinum-combination chemotherapy and subsequent radiotherapy in previously untreated patients with advanced squamous c google schola Glisson BS / 2002 / Phase II trial of docetaxel and cisplatin combination chemotherapy in patients with squamous cell carcinoma of the head and neck 20 : 1593 ~ 99 google schola

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