비인강암의 치료방법에서 Docetaxel과 Platinum을 이용한 유도항암요법의 효과

공일승; 양윤수; 최동일; 권삼현; 홍기환

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자료유형: 학술저널

저자정보: 공일승 양윤수 최동일 권삼현 홍기환

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제51권 제1호

발행연도: 2008.1

수록면: 58 - 63 (6page)

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연구주제

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연구배경

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연구방법

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연구결과

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The aim of this study was to determine the efficacy of induction chemotherapy with docetaxel and platinum in patients with nasopharyngeal carcinoma. Subjects and Method：The medical records of 52 patients, who were diagnosed with NPC at our department from January 1995 to December 2005, were reviewed and retrospectively analyzed. Patients were divided into three groups according to treatment methods. Twenty-eight cases treated with induction chemotherapy consisted of docetaxel, platinum and RT, 17 cases treated with induction chemotherapy consisted of 5-FU, platinum and RT, and 7 cases were treated with RT only. A total of 114 chemotherapy cycles were administered to patients and most received 2 cycles. Results：The T stage distribution at the time of diagnosis was 48%, 14%, 15%, and 23% for T1, T2, T3 and T4, respectively. According to the WHO classification, the type I included 11 cases, type II 2cases, and type III 39 cases. The overall 5-year survival rate was 60.6%. According to the treatment modality, only the RT group was 42.9%. In the chemoradiotherapy group, the 5-year survival rates of 5-FU and platinum combination group and docetaxel and platinum combination group were 47.1% and 78.8%, respectively. There was significant difference in survival (p=0.037). There was no difference in sex, age, and N stage with regards to the 5-year survival rate. Conclusion：Although no valid conclusions could be drawn because of the small number of patients examined in the present study, we found that induction chemotherapy consists of docetaxel and that platinum may improve the outcome of patients with NPC. (Korean J Otorhinolaryngol-Head Neck Surg 2008;51:58-63)

#Nasopharyngeal carcinoma·Chemotherapy·Treatment outcome.

참고문헌 (15)

참고문헌 신청

Altun M / 1995 / Undifferentiated nasopharyngeal cancer (UCNT): Current diagnosis and the-rapeutic aspects / Int J Radiat Oncol Biol Phys 32 (3) : 859 ~ 877

Catimel G / 1994 / Docetaxel (Taxotere): An active drug for the treatment of patients with advanced squamous cell carcinoma of the head and neck. EORTC Early Clinical Trials

Choo R / 1991 / Chemotherapy for recurrent or metastatic carcinoma of the nasopharyx. A review of the Princess Nargaret Hospital experience / Cancer 68 (10) : 2120 ~ 2124

Colevas AD / 2002 / Phase I/II trial of outpatient docetaxel, cisplatin, 5-fluorouracil, leucovorin (op TPFL) as induction for squamous cell carcinoma of the head and neck (S

Cooper JS / 2000 / Concurrent chemotherapy and radiation therapy for advanced stage carcinoma of the nasopharynx / Int J Radiat Oncol Biol Phys 48 (5) : 1277 ~ 1279

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