지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 937 - 942 (6page)
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We describe two cases of pulmonary arterial hypertension (PAH) that occurred underdasatinib treatment and were resolved after dasatinib discontinuation. Two patientswith chronic phase chronic myeloid leukemia (CML) were switched to dasatinib therapybecause of hematological progress while receiving imatinib. These patients hadNew York Heart Association (NYHA) functional class II dyspnea with elevated rightventricular systolic pressure (RVSP), which progressed under dasatinib treatment.
After dasatinib treatment was discontinued, subjective symptoms were improved toNYHA functional class I and the follow-up transthoracic Doppler echocardiographyshowed improved RVSP. Treatment with an alternate tyrosine kinase inhibitor wasinitiated and had been continued without development of dyspnea or elevation ofRVSP. This report suggests that dasatinib can cause the reversible PAH, therefore,routine cardiopulmonary evaluation before and during treatment with dasatinib maybe needed in CML patients with clinical manifestations.
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등록된 정보가 없습니다.
참고문헌 (15)
참고문헌 신청
Balasubramaniam V / 2003 / Role of platelet-derived growth factor in vascular remodeling during pulmonary hypertension in the ovine fetus / Am J Physiol Lung Cell Mol Physio
Dumitrescu D / 2011 / Fully reversible pulmonary arterial hypertension associated with dasatinib treatment for chronic myeloid leukaemia / Eur Respir J 38 : 218 ~ 220
Galie N / 2009 / Guidelines for the diagnosis and treatment of pulmonary hypertension : the Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the Europe
Ghofrani HA / 2010 / Imatinib in pulmonary arterial hypertension patients with inadequate response to established therapy / Am J Respir Crit Care Med 182 : 1171 ~ 1177
Hennigs JK / 2011 / Multi tyrosine kinase inhibitor dasatinib as novel cause of severe pre-capillary pulmonary hypertension? / BMC Pulm Med : 11 ~ 30
Dumitrescu D / 2011 / Fully reversible pulmonary arterial hypertension associated with dasatinib treatment for chronic myeloid leukaemia / Eur Respir J 38 : 218 ~ 220
Galie N / 2009 / Guidelines for the diagnosis and treatment of pulmonary hypertension : the Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the Europe
Ghofrani HA / 2010 / Imatinib in pulmonary arterial hypertension patients with inadequate response to established therapy / Am J Respir Crit Care Med 182 : 1171 ~ 1177
Hennigs JK / 2011 / Multi tyrosine kinase inhibitor dasatinib as novel cause of severe pre-capillary pulmonary hypertension? / BMC Pulm Med : 11 ~ 30
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