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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 645 - 652 (8page)
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Purpose This study was conducted to evaluate the treatment outcomes following definitive bimodalityconcurrent chemoradiotherapy (CCRT) in patients with inoperable N2-positive stage IIIA (N2-IIIA) non-small cell lung cancer (NSCLC).
Materials and MethodsFrom May 1997 to December 2012, 65 out of 633 patients with N2-IIIA NSCLC receivedbimodality therapy. The treatment modality was selected during/after neoadjuvant CCRTin 21 patients or primarily at diagnosis in 44 through a multidisciplinary consensus meeting.
The median age was 65 years (range, 36 to 76 years). Sixty patients (92.3%) had clinicallyevident N2 disease, while 22 (33.8%) had multi-station N2 involvement. The median radiationtherapy dose was 66 Gy in 33 fractions, while the dose was elevated to 72 Gy in 13patients who had a treatment break due to delayed decision regarding resectability. Themost frequent chemotherapy regimen was weekly paclitaxel or docetaxel plus cisplatin orcarboplatin (54, 83.1%).
ResultsDuring the median follow-up of 18.8 months (range, 1.6 to 173.1 months), 34 patients(52.3%) experienced disease progression, with distant metastasis being the most commonfirst treatment failure pattern (23, 34.8%). The median and 2-year rates of progression-freesurvival were 18.8 months and 45.9%, respectively. The median and 2-year rates of overallsurvival were 28.6 months and 50.1%, respectively.
ConclusionDefinitive bimodality therapy in patients with N2-IIIA NSCLC demonstrated favorable outcomes,while trimodality therapy could be considered for candidates for less than pneumonectomy.
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참고문헌 (17)
참고문헌 신청
Albain KS / 2009 / Radiotherapy plus chemotherapy with or without surgical resection for stage III non-small-cell lung cancer : a phase III randomised controlled trial / Lanc
Curran WJ Jr / 2011 / Sequential vs. concurrent chemoradiation for stage III non-small cell lung cancer: randomized phase III trial RTOG 9410 / J Natl Cancer Inst 103 : 1452
Eroglu C / 2013 / Concomitant chemoradiotherapy with docetaxel and c isplatin followed by consolidation chemotherapy in locally advanced unresectable non-small cell lung can
Fournel P / 2005 / Randomized phase III trial of sequential chemoradiotherapy compared with concurrent chemoradiotherapy in locally advanced non-small-cell lung cancer : Grou
Koshy M / 2013 / Improved survival associated with neoadjuvant chemoradiation in patients with clinical stage IIIA(N2)non-small-cell lung cancer / J Thorac Oncol 8 : 915 ~ 92
Curran WJ Jr / 2011 / Sequential vs. concurrent chemoradiation for stage III non-small cell lung cancer: randomized phase III trial RTOG 9410 / J Natl Cancer Inst 103 : 1452
Eroglu C / 2013 / Concomitant chemoradiotherapy with docetaxel and c isplatin followed by consolidation chemotherapy in locally advanced unresectable non-small cell lung can
Fournel P / 2005 / Randomized phase III trial of sequential chemoradiotherapy compared with concurrent chemoradiotherapy in locally advanced non-small-cell lung cancer : Grou
Koshy M / 2013 / Improved survival associated with neoadjuvant chemoradiation in patients with clinical stage IIIA(N2)non-small-cell lung cancer / J Thorac Oncol 8 : 915 ~ 92
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