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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 43 - 48 (6page)
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초록· 키워드
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Objective: The present study aimed to determine the intracellular action of the antidepressant, venlafaxine, in C6 glioma cells using heat shock protein 70 (HSP70) immunocytochemistry and HSP70 Western blots; HSP70 is known to be associated with stress and depression.
Methods: The extent of HSP70 expression was measured after rat C6 glioma cells were treated with 1) dexamethasone only, 2) venlafaxine only, 3) simultaneous venlafaxine and dexamethasone, or 4) dexamethasone after venlafaxine pretreatment. Dexamethasone (10 μM, 6 hours) did not affect the level of HSP70 expression relative to control.
Results: Short-term (1 hour) venlafaxine treatment significantly increased the level of HSP 70 expression. Simultaneous long-term (72 hours) venlafaxine and dexamethasone treatment significantly reduced the level of HSP70 expression. Dexamethasone treatment administered following long-term (24 and 72 hours) pretreatment with venlafaxine also significantly reduced the level of HSP70 expression.
Conclusion: Short-term treatment with venlafaxine increases the expression of HSP70, but prolonged treatment with dexamethasone suppresses the venlafaxine-induced expression of HSP70. These findings suggest that HSP70 and dexamethasone play a significant role in the pathophysiology of depression.
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등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Chen J / 1995 / Chronic treatment of C6 glioma cells with antidepressant drugs increases functional coupling between a G protein (Gs) and adenylyl cyclase / J Neurochem 64 :
Duman RS / 1997 / A molecular and cellular theory of depression / Arch Gen Psychiatry 54 : 597 ~ 606
Fishman PH / 1987 / Effect of tricyclic antidepressant desipramine on beta-adrenergic receptors in cultured rat glioma C6 cells / J Neurochem 49 : 282 ~ 289
Gold PW / 1988 / Clinical and biochemical manifestations of depression. Relation to the neurobiology of stress (2) / N Engl J Med 319 : 413 ~ 420
Heim C / 2008 / The dexamethasone/corticotropin-releasing factor test in men with major depression: role of childhood trauma / Biol Psychiatry 63 : 398 ~ 405
Duman RS / 1997 / A molecular and cellular theory of depression / Arch Gen Psychiatry 54 : 597 ~ 606
Fishman PH / 1987 / Effect of tricyclic antidepressant desipramine on beta-adrenergic receptors in cultured rat glioma C6 cells / J Neurochem 49 : 282 ~ 289
Gold PW / 1988 / Clinical and biochemical manifestations of depression. Relation to the neurobiology of stress (2) / N Engl J Med 319 : 413 ~ 420
Heim C / 2008 / The dexamethasone/corticotropin-releasing factor test in men with major depression: role of childhood trauma / Biol Psychiatry 63 : 398 ~ 405
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