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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 313 - 315 (3page)
이용수
초록· 키워드
오류제보하기
Bupropion is a selective norepinephrine and dopamine reuptake inhibitor with no serotonergic activity, and is therefore an antidepressant with unique pharmacological properties.
There are some reports that selective serotonin reuptake inhibitors (SSRIs) or mirtazapine can induce adverse effects including restless legs syndrome (RLS) and that bupropion can reverse these adverse effects. Here, we report about a patient with a major depressive disorder who exhibited RLS after being treated with pregabalin and mirtazapine. This adverse effect disappeared after having switched from mirtazapine to bupropion. Bupropion inhibits the reuptake of dopamine and increases dopamine neurotransmission in both the nucleus accumbens and the prefrontal cortex. This pharmacological profile can be effective in patients with RLS related to dopamine hypoactivity. However, the limitations of this single case report mean that further investigations with larger samples are needed.
목차
등록된 정보가 없습니다.
참고문헌 (19)
참고문헌 신청
Allen RP / 2003 / Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology w
Allen RP / 2005 / Restless legs syndrome prevalence and impact: REST general population study / Arch Intern Med 165 : 1286 ~ 1292
Cunningham MO / 2004 / Dual effects of gabapentin and pregabalin on glutamate release at rat entorhinal synapses in vitro / Eur J Neurosci 20 : 1566 ~ 1576
Demyttenaere K / 2008 / Review: bupropion and SSRI-induced side effects / J Psychopharmacol 22 : 792 ~ 804
Dooley DJ / 2000 / Stimulus-dependent modulation of [(3)H] norepinephrine release from rat neocortical slices by gabapentin and pregabalin / J Pharmacol Exp Ther 295 : 1086
Allen RP / 2005 / Restless legs syndrome prevalence and impact: REST general population study / Arch Intern Med 165 : 1286 ~ 1292
Cunningham MO / 2004 / Dual effects of gabapentin and pregabalin on glutamate release at rat entorhinal synapses in vitro / Eur J Neurosci 20 : 1566 ~ 1576
Demyttenaere K / 2008 / Review: bupropion and SSRI-induced side effects / J Psychopharmacol 22 : 792 ~ 804
Dooley DJ / 2000 / Stimulus-dependent modulation of [(3)H] norepinephrine release from rat neocortical slices by gabapentin and pregabalin / J Pharmacol Exp Ther 295 : 1086
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