지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 214 - 218 (5page)
이용수
초록· 키워드
오류제보하기
ObjectiveaaThe goal of this study was to evaluate the importance of nesfatin-1, acylated and des-acylated ghrelin, which are known as energy regulatory hormones, in patients with moderate and severe major depression disorders (MDD). MethodsaaThirty patients with a moderate degree of MDD and, 30 with a severe degree of MDD were used as participants in this study. Thirty subjects without depression were enrolled as a control group. The Hamilton Depression Rating Scale was used to classify the patients with MDD. Blood samples were taken after overnight fasting. The plasma nesfatin-1, acylated ghrelin and des-acylated ghrelin levels were measured using a commercially available enzyme-linked immunosorbent assay kit. ResultsaaThe nesfatin-1, the acylated ghrelin and the des-acylated ghrelin levels were found to be significantly higher in severe MDD (3.92±0.4 ng/mL; 88.56±4.1 pg/mL; 962.76±67 pg/mL) as compared to moderate MDD (2.91±0.5 ng/mL; 77.63±4.19 pg/mL; 631.16± 35 pg/mL), or the control (1.01±0.3 ng/mL; 58.60±9.00 pg/mL; 543.13±62 pg/mL), respectively. ConclusionaaAlthough nesfatin-1 and ghrelin are known as adversely affecting the hormones involving the regulation of appetite and food intake, they all increase in depressive patients and are even associated with the severity of the disease. In clinical medicine, the evaluation of the role of nesfatin-1 and ghrelin in endocrine and neu-roendocrine regulation of major metabolic functions is an important key mechanism in solving numerous diseases associated with endocrine and neuroendocrine disturbance. Increased levels of nesfatin-1 and ghrelin may also be important criteria in describing the prognoses of the patients and the effectiveness of the treatments.
목차
등록된 정보가 없습니다.
참고문헌 (38)
참고문헌 신청
Mischoulon D / 2010 / Depression and eating disorders: treatment and course / J Affect Disord 130:470~477
de Kloet ER / 2005 / Stress and the brain: from adaptation to disease / Nat Rev Neurosci 6:463~475
Serova LI / 2014 / Blockage of melanocortin-4 receptors by intranasal HS014 attenuates single prolonged stresstriggered changes in several brain regions / J Neurochem 131:825~835
Ari M / 2011 / High plasma nesfatin-1 level in patients with major depressive disorder / Prog Neuropsychopharmacol Biol Psychiatry 35:497~500
Bloem B / 2012 / Sex-specific differences in the dynamics of cocaine- and amphetamineregulated transcript andnesfatin-1 expressions in the midbrain of depressed suicide victims vs. controls / Neuropharmacology 62:297~303
de Kloet ER / 2005 / Stress and the brain: from adaptation to disease / Nat Rev Neurosci 6:463~475
Serova LI / 2014 / Blockage of melanocortin-4 receptors by intranasal HS014 attenuates single prolonged stresstriggered changes in several brain regions / J Neurochem 131:825~835
Ari M / 2011 / High plasma nesfatin-1 level in patients with major depressive disorder / Prog Neuropsychopharmacol Biol Psychiatry 35:497~500
Bloem B / 2012 / Sex-specific differences in the dynamics of cocaine- and amphetamineregulated transcript andnesfatin-1 expressions in the midbrain of depressed suicide victims vs. controls / Neuropharmacology 62:297~303
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Nesfatin-1 Hormone Levels in Patients with Antisocial Personality Disorder and Their Relationship with Clinical Variables
PSYCHIATRY INVESTIGATION
2020 .01
-
Anti-inflammatory and antifatigue effect of Korean Red Ginseng in patients with nonalcoholic fatty liver disease
Journal of Ginseng Research
2016 .07
-
Leptin, Nesfatin-1, Orexin-A, and Total Ghrelin Levels in Drug-Naive Panic Disorder
PSYCHIATRY INVESTIGATION
2024 .02
-
Multiple Complement Pathway-related Proteins Might Regulate Immunopathogenesis of Major Depressive Disorder
Clinical Psychopharmacology and Neuroscience
2023 .05
-
성인 아토피 피부염 환자의 우울증 동반에 따른 점증적 비용 부담: 후향적 단면연구
보건의료기술평가
2021 .12
-
Serum S100B Protein Levels in Patients with Panic Disorder: Effect of Treatment with Selective Serotonine Reuptake Inhibitors
PSYCHIATRY INVESTIGATION
2015 .01
-
Biomarkers of Major Depressive Disorder: Knowing is Half the Battle
Clinical Psychopharmacology and Neuroscience
2021 .01
-
Gender Differences in Depressive Symptom Profile: Results from Nationwide General Population Surveys in Korea
Journal of Korean Medical Science
2015 .01
-
주요우울장애 환자의 기질 및 심리 특성: 외상 및 스트레스 관련 장애와 비교
정신분석
2019 .01
-
BeMicroarray Analysis of the Major Depressive Disorder mRNA Profile Data
PSYCHIATRY INVESTIGATION
2015 .01
-
Comparison of Electroencephalography (EEG) Coherence between Major Depressive Disorder (MDD) without Comorbidity and MDD Comorbid with Internet Gaming Disorder
Journal of Korean Medical Science
2017 .01
-
Diagnostic Issues of Depressive Disorders from Kraepelinian Dualism to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition
PSYCHIATRY INVESTIGATION
2019 .01
-
Bidirectional Association between First-Episode Panic Disorder and Major Depressive Disorder in a Nationwide General Population Survey in Korea
Journal of Korean Medical Science
2019 .01
-
Serum Cytokine Levels in Major Depressive Disorder and Its Role in Antidepressant Response
PSYCHIATRY INVESTIGATION
2016 .01
-
Reduced Temporal Activation During a Verbal Fluency Task is Associated with Poor Motor Speed in Patients with Major Depressive Disorder
PSYCHIATRY INVESTIGATION
2020 .01
-
Expected Emotional Usefulness and Emotional Preference in Individuals with Major Depressive Disorder
Clinical Psychopharmacology and Neuroscience
2016 .01
-
주요우울장애를 동반한 공황장애 환자군의 임상적 특징
생물정신의학
2018 .01
-
Frontal Alpha Asymmetry Moderated by Suicidal Ideation in Patients with Major Depressive Disorder: A Comparison with Healthy Individuals
Clinical Psychopharmacology and Neuroscience
2020 .01
-
The Relationship of Lifestyle Factors with the Prevalence of Major Depressive Disorder by Ecological Factors
PSYCHIATRY INVESTIGATION
2021 .01
-
Comparison of Autonomic Reactivity to the Stress between Adjustment Disorder and Major Depressive Disorder
PSYCHIATRY INVESTIGATION
2020 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0