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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 200 - 204 (5page)
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초록· 키워드
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ObjectiveaaSeasonal affective disorder and seasonal changes in mood and behavior are associated with several genes that regulate circadian rhythms. In this study, we investigated the relationship between the C825T polymorphism of the G-protein β3 subunit and seasonal variations in mood and behavior in a young healthy Korean population. MethodsaaA total of 507 young Korean participants were recruited through a newspaper advertisement, and their seasonality was evaluated by the Korean version of the Seasonal Pattern Assessment Questionnaire to assess the global seasonality score (GSS). We analyzed the CC, CT, and TT genotypes and their association with the GSS score and subscales. ResultsaaT allele carriers of the GNB3 C825T polymorphism were more likely to score higher on body weight and GSS. In the female group, the T allele carriers obtained significantly high total GSS and its subscale scores for mood, body weight, energy level, and appetite; however, differences in genotypes and allele carriers were also observed in the male participants. ConclusionaaThese results suggested that GNB3 C825T polymorphism plays a role in seasonal variations in mood, body weight, energy level, and appetite in a Korean population, particularly in females.
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참고문헌 (35)
참고문헌 신청
Rosenthal NE / 1984 / Seasonal affective disorder. A description of the syndrome and preliminary findings with light therapy / Arch Gen Psychiatry 41:72~80
Association AP / 2013 / Diagnostic and Manual of Mental Disorders (DSM-$5^{(R)}$ ) / American Psychiatric Pub
Partonen T / 1998 / Seasonal affective disorder / Lancet 352:1369~1374
Lam RW / 2000 / Pathophysiology of seasonal affective disorder: a review / J Psychiatry Neurosci 25:469~480
Gould TD / 2002 / Signaling networks in the pathophysiology and treatment of mood disorders / J Psychosom Res 53:687~697
Association AP / 2013 / Diagnostic and Manual of Mental Disorders (DSM-
Partonen T / 1998 / Seasonal affective disorder / Lancet 352:1369~1374
Lam RW / 2000 / Pathophysiology of seasonal affective disorder: a review / J Psychiatry Neurosci 25:469~480
Gould TD / 2002 / Signaling networks in the pathophysiology and treatment of mood disorders / J Psychosom Res 53:687~697
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