지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 211 - 215 (5page)
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초록· 키워드
오류제보하기
Objective: Restless legs syndrome (RLS) has been reported to be more prevalent in schizophrenic patients who take antipsychotics. The cause of RLS is unknown but associated with dopaminergic deficiency. Tyrosine hydroxylase (TH) is the enzyme responsible for catalyzing the conversion of L-tyrosine to DOPA. The purpose of this study is to determine whether
the TH gene Val81Met polymorphism is associated with antipsychotic-induced RLS.
Methods: One hundred ninety Korean schizophrenic patients were evaluated by the diagnostic criteria of the International RLS Study Group (IRLSSG). The genotyping was performed by PCR-based methods.
Results: Of the one hundred ninety schizophrenic patients, 44 (23.2%) were found to have RLS. Although there were no significant associations between TH genotypes or allele frequencies and RLS, when separate analyses were performed by sex (male or female), we detected significant differences in the frequencies of the genotype (χ2=6.15, p=0.046) and allele (χ2=4.67, p=0.031) of the TH gene Val81Met polymorphism between those with and without RLS in the female patients.
Conclusion: These findings suggest that the TH gene Val81Met SNP might be associated with antipsychotic-induced RLS in female schizophrenic patients.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Allen RP / 2003 / Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology w
Benmoyal-Segal L / 2006 / Gene-environment interactions in sporadic Parkinson’s disease / J Neurochem 97 : 1740 ~ 1755
Bjorvatn B / 2005 / Prevalence, severity and risk factors of restless legs syndrome in the general adult population in two Scandinavian countries / Sleep Med 6 : 307 ~ 312
Chang Ho Yun MD / 2006 / Pathophysiology of the Restless Legs Syndrome:dopamine and Iron / J Kor Sleep Soc 3 : 22 ~ 28
Chitbangonsyn SW / 2003 / Physical mapping of autonomic/sympathetic candidate genetic loci for hypertension in the human genome: a somatic cell radiation hybrid library appr
Benmoyal-Segal L / 2006 / Gene-environment interactions in sporadic Parkinson’s disease / J Neurochem 97 : 1740 ~ 1755
Bjorvatn B / 2005 / Prevalence, severity and risk factors of restless legs syndrome in the general adult population in two Scandinavian countries / Sleep Med 6 : 307 ~ 312
Chang Ho Yun MD / 2006 / Pathophysiology of the Restless Legs Syndrome:dopamine and Iron / J Kor Sleep Soc 3 : 22 ~ 28
Chitbangonsyn SW / 2003 / Physical mapping of autonomic/sympathetic candidate genetic loci for hypertension in the human genome: a somatic cell radiation hybrid library appr
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