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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 204 - 210 (7page)
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초록· 키워드
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Objective: Mental fatigue, cognitive disorders, and sleep disturbances seen in chronic fatigue syndrome (CFS) may be attributed to cholinergic deficit. A functional deficiency of cholinergic neurotransmission may cause the hypothalamic-pituitary-adrenal axis hypoactivity seen in CFS. Therefore, we investigated the alterations in stress hormones such as cortisol and dehydroepiandrosterone sulfate (DHEAS) in CFS patients before and after 4-
week administration of galantamine hydrobromide, a selective cetylcholinesterase inhibitor, and aimed to investigate whether there are any relationships between the probable hormonal changes and cholinergic treatment.
Methods: Basal levels of cortisol and DHEAS were measured in 29 untreated CFS patients who were diagnosed according to Centers for Disease Control (CDC) criteria and in 20 healthy controls. In the patient group, four weeks after 8 ㎎/d galantamine hydrobromide treatment, cortisol and DHEAS levels were measured again. After the treatment 22 patients who stayed in study were divided into two subgroups as responders and nonresponders
according to the reduction in their Newcastle Research Group ME/CFS Score Card (NRG) scores.
Results: Important findings of this study are lower pre-and post-treatment cortisol levels and in all CFS patients compared to controls (F=4.129, p=0.049; F=4.803, p=0.035, respectively); higher basal DHEAS values and higher DHEAS/cortisol molar ratios which were normalized following four weeks’ treatment with 8 ㎎/d galantamine hydrobromide in the treatment-respondent group (F=5.382, p=0.029; F=5.722, p=0.025, respectively).
Conclusion: The findings of the decrease in basal DHEAS levels and DHEAS/cortisol molar ratios normalizing with galantamine treatment may give some support to the cholinergic deficit hypothesis in CFS.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
[학술지(정기
Cleare AJ / 2001 / Hypothalamo-pituitary-adrenal axis function in chronic fatigue syndrome and the effects of low-dose hydrocortisone therapy / J Clin Endocrinol Metab 86 : 3
Cleare AJ / 2001 / Urinary free cortisol in chronic fatigue syndrome / Am J Psychiatry 158 : 641 ~ 643
Cozanitis DA / 1974 / Galantamine hydrobromide versus neostigmine. A plasma cortisol study in man / Anaesthesia 29 : 163 ~ 168
De Becker P / 1999 / Dehydroepiandrosterone (DHEA) response to i.v. ACTH in patients with chronic fatigue syndrome / Horm and Metab Res 31 : 18 ~ 21
Cleare AJ / 2001 / Hypothalamo-pituitary-adrenal axis function in chronic fatigue syndrome and the effects of low-dose hydrocortisone therapy / J Clin Endocrinol Metab 86 : 3
Cleare AJ / 2001 / Urinary free cortisol in chronic fatigue syndrome / Am J Psychiatry 158 : 641 ~ 643
Cozanitis DA / 1974 / Galantamine hydrobromide versus neostigmine. A plasma cortisol study in man / Anaesthesia 29 : 163 ~ 168
De Becker P / 1999 / Dehydroepiandrosterone (DHEA) response to i.v. ACTH in patients with chronic fatigue syndrome / Horm and Metab Res 31 : 18 ~ 21
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