지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Early-life stress (ELS), a complex traumatic stress including abuse, neglect and bullying during childhood or adolescence, is closely related to the development of psychiatric disorders. Conduct of a prospective study on the effect of ELS in human subjects is difficult due to ethical issues and limitations, and animal model study can be a reasonable alternative. Articles regarding structural and functional changes in the animal brain associated with ELS have been reviewed in this study. An up-to-date literature search on the effect of ELS on animal brain was performed ; keywords included ELS, central nervous system (CNS), and animal study using PubMed. A total of 623 articles were found and important articles were reviewed. First, we summarized the neurobiological changes in CNS associated with ELS, and then the effects of ELS on emotional and cognitive function and behavioral characteristics were recapped. ELS can induce overreactivity of the hypothalamus-pituitary-adrenal axis and cortical-subcortical structural changes including prefrontal cortex, hippocampus, and amygdala. These changes may be associated with neuroendocrine, cognitive, and emotional dysfunctions and related behavioral changes. Although most animal model studies used a single mode of stress, ELS tends to be experienced with complex types in human-life. Design of a new animal model examining the effects of complex trauma during early-life is important. Studies on the association between complex trauma and brain development can provide important insights regarding the pathogenetic mechanism of complex psychiatric disorders such as personality disorder and treatment-resistant depression.
목차
등록된 정보가 없습니다.
참고문헌 (105)
참고문헌 신청
Pechtel P / 2011 / Effects of early life stress on cognitive and affective function: an integrated review of human literature / Psycho-pharmacology (Berl) 214:55~70
2000 / Committee on Integrating the Science of Early Childhood Development, Board on Children, Youth, and Families, Institute of Medicine, Division of Behavioral and Social Sciences and Education. From neurons to neighborhoods: the science of early childhood development / National Academies Press
Taylor SE / 2010 / Mechanisms linking early life stress to adult health outcomes / Proc Natl Acad Sci U S A 107:8507~8512
Kaufman J / 1991 / Depressive disorders in maltreated children / J Am Acad Child Adolesc Psychiatry 30:257~265
Jumper SA / 1995 / A meta-analysis of the relationship of child sexual abuse to adult psychological adjustment / Child Abuse Negl 19:715~728
2000 / Committee on Integrating the Science of Early Childhood Development, Board on Children, Youth, and Families, Institute of Medicine, Division of Behavioral and Social Sciences and Education. From neurons to neighborhoods: the science of early childhood development / National Academies Press
Taylor SE / 2010 / Mechanisms linking early life stress to adult health outcomes / Proc Natl Acad Sci U S A 107:8507~8512
Kaufman J / 1991 / Depressive disorders in maltreated children / J Am Acad Child Adolesc Psychiatry 30:257~265
Jumper SA / 1995 / A meta-analysis of the relationship of child sexual abuse to adult psychological adjustment / Child Abuse Negl 19:715~728
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