지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objectives：Bipolar disorder is known to have a high genetic predisposition. Recently, the main focus of etiologic studies in bipolar disorder has been concentrated on molecular genetic approach including gene polymorphism analysis. The present study was conducted to investigate whether TNFB polymorphism is associated with bipolar I disorder in the Korean population.
Methods：89 bipolar I disorder patients diagnosed by DSM-IV criteria were assigned as the patient group and 202 normal population, matched on age and sex from Catholic hemopoietic stem cell bank (Seoul, Korea), were enrolled as the control group in this study. Genotyping was performed by a polymerase chain reaction-restriction fragment length polymorphism method. All data was analyzed by χ2 test. Results：There were no significant differences in frequency of TNFB*1/1, TNFB*1/2 and TNFB*2/2 between bipolar I disorder patient group and normal control group. The frequency of TNFB*2 and TNFB*1 was not statistically different between bipolar I disorder patient group and normal control group.
Conclusion：The difference of frequency in TNFB*1/TNFB*2 gene between the bipolar I disorder gropup and the normal control could not be verified. The present result suggested that the gene polymorphism of TNFB may not play a significant role in susceptibility to bipolar I disorder. Studies with a larger number of subjects from different ethnic backgrounds, considering clinical phenotype and controlling various factors, should be launched to further determine the role of TNFB in bipolar I disorder.
목차
등록된 정보가 없습니다.
참고문헌 (28)
참고문헌 신청
/ 1982 / Humoral autoimmune phenomena under longterm treatment with lithium with special regard to thyroid auto antibodies 60 : 1501 ~ 1504
/ 1987 / The neuropsychiatric effects of treatment with interleukin-2and lymphokine-activated killer cells 107 : 293 ~ 300
/ 1987 / Visualization andcharacterization of interleukin 1 receptors in brain 139 : 459 ~ 463
/ 1988 / A simple salting out procedure forextracting DNA from human nucleated acid 16 : 1215 ~
/ 1988 / Differential effect of mixed D1/D2 and selective D2 dopaminergic antagonists on mouse T and Blymphocyte proliferation and interleukin production in vitro 10 : 501 ~
/ 1987 / The neuropsychiatric effects of treatment with interleukin-2and lymphokine-activated killer cells 107 : 293 ~ 300
/ 1987 / Visualization andcharacterization of interleukin 1 receptors in brain 139 : 459 ~ 463
/ 1988 / A simple salting out procedure forextracting DNA from human nucleated acid 16 : 1215 ~
/ 1988 / Differential effect of mixed D1/D2 and selective D2 dopaminergic antagonists on mouse T and Blymphocyte proliferation and interleukin production in vitro 10 : 501 ~
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