지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 196 - 201 (6page)
이용수
초록· 키워드
오류제보하기
ObjectiveaaCHRNA7 has been shown to be a strong candidate gene for schizophrenia and bipolar disorder. It is located on chromosome 15q13-q14, which is one of the replicated linkage spots for schizophrenia and bipolar disorder.
MethodsaaWe conducted an association study to determine whether previous positive association is replicable in the Korean population.
We included 254 patients with schizophrenia, 193 patients with bipolar disorder type I, 38 patients with bipolar disorder type II, 64 schizoaffective disorder patients, and 349 controls. All subjects were ethnically Korean. A total of 898 subjects were included, and genotyping was done for three single nucleotide polymorphisms (SNPs) of CHRNA7. These three intronic SNPs were rs2337506 (A/G), rs6494223 (C/T), and rs12916879 (A/G).
ResultsaaThere was only one marginally significant association; this association was between rs12916879 and bipolar disorder type I in the male subgroup. In both the allele and genotype distributions, we found a weak signal (Chi-squared=3.57, df=1, p=0.06 for allele, Chi-squared=7.50, df=2, p=0.02 for genotype) only. Unphased haplotype analysis could not provide additional support for this finding. No SNP was associated with schizophrenia or any other affected groups in this Korean sample. The associative finding is marginal and inconclusive.
ConclusionaaWe could not replicate positive association in other ethnic groups previously studied. This suggests possible heterogeneity in the genes associated with schizophrenia and bipolar disorders. Because of structural complexity of the CHRNA7 gene and the limited statistical power of this study, further genetic studies with more SNPs and larger samples covering various populations, along with more fine molecular exploration of the CHRNA7 gene structure, are required.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
[학술지(정기간행물
Adler LE / 1982 / Neurophysiological evidence for a defect in neuronal mechanisms involved in sensory gating in schizophrenia / Biol Psychiatry 17 : 639 ~ 654
Adler LE / 1998 / Schizophrenia, sensory gating, and nicotinic receptors / Schizophr Bull 24 : 189 ~ 202
Badner JA / 2002 / Meta-analysis of whole-genome linkage scans of bipolar disorder and schizophrenia / Mol Psychiatry 7 : 405 ~ 411
Baker N / 1987 / Neurophysiological assessment of sensory gating in psychiatric inpatients: comparison between schizophrenia and other diagnoses / Biol Psychiatry 22 : 603 ~
Adler LE / 1982 / Neurophysiological evidence for a defect in neuronal mechanisms involved in sensory gating in schizophrenia / Biol Psychiatry 17 : 639 ~ 654
Adler LE / 1998 / Schizophrenia, sensory gating, and nicotinic receptors / Schizophr Bull 24 : 189 ~ 202
Badner JA / 2002 / Meta-analysis of whole-genome linkage scans of bipolar disorder and schizophrenia / Mol Psychiatry 7 : 405 ~ 411
Baker N / 1987 / Neurophysiological assessment of sensory gating in psychiatric inpatients: comparison between schizophrenia and other diagnoses / Biol Psychiatry 22 : 603 ~
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