지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 107 - 119 (13page)
이용수
초록· 키워드
오류제보하기
Background and Purpose Conventional therapies for ischemic stroke include thrombolytic
therapy, prevention of inappropriate coagulation and thrombosis, and surgery to repair vascular
abnormalities. Over 10 years have passed since the US Food and Drug Administration approved
intravenous tissue plasminogen activator for use in acute stroke patients, but most major
clinical trials have failed during the last 2 decades, including large clinical trials for secondary
prevention and neuroprotection. These results suggest the presence of heterogeneity among stroke
patients. Neuroimaging techniques now allow changes to be observed in patients from the acute
to the recovery phase. The role of MRI in stroke evaluation and treatment is discussed herein.
Main Contents Three MRI strategies are discussed with relevant examples. First, the following
MRI strategies for acute ischemic stroke are presented: diffusion-perfusion mismatch,
deoxygenation (oxygen extraction and cerebral metabolic rate of oxygen), and blood-brain
barrier permeability derangement in selected patients for recanalization therapy. Second, multimodal
MRI for identifying stroke mechanisms and the specific causes of stroke (i.e., patent
foramen ovale, infective endocarditis, and nonbacterial thrombotic endocarditis) are presented,
followed by MRI strategies for prevention of recurrent stroke: plaque images and flow dynamics
for carotid intervention.
Expectations The studies reviewed herein suggest that using MRI to improve the understanding
of individual pathophysiologies will further promote the development of rational stroke therapies
tailored to the specifics of each case.
목차
등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Adams HP Jr / 2007 / Guidelines for the early management of adults with ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke C
Adams HP Jr / 2008 / Emergency administration of abciximab for treatment of patients with acute ischemic stroke: results of an international phase III trial: Abciximab in Eme
Bhatt DL / 2006 / Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events / N Engl J Med 354 : 1706 ~ 1717
Caplan LR / 2001 / Evidence based medicine: concerns of a clinical neurologist / J Neurol Neurosurg Psychiatry 71 : 569 ~ 574
Chimowitz MI / 2005 / Comparison of warfarin and aspirin for symptomatic intracranial arterial stenosis / N Engl J Med 352 : 1305 ~ 1316
Adams HP Jr / 2008 / Emergency administration of abciximab for treatment of patients with acute ischemic stroke: results of an international phase III trial: Abciximab in Eme
Bhatt DL / 2006 / Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events / N Engl J Med 354 : 1706 ~ 1717
Caplan LR / 2001 / Evidence based medicine: concerns of a clinical neurologist / J Neurol Neurosurg Psychiatry 71 : 569 ~ 574
Chimowitz MI / 2005 / Comparison of warfarin and aspirin for symptomatic intracranial arterial stenosis / N Engl J Med 352 : 1305 ~ 1316
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