지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 227 - 233 (7page)
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초록· 키워드
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Background and Purpose Acute myelitis patients exhibiting only sensory defcits upon initial presentation are not commonly encountered in clinical practice, but they defnitely exist. Since acute sensory myelitis has not been investigated previously, this study evaluated the etiological spectrum of the condition with the aim of describing the clinical characteristics thereof.
Methods Patients with acute myelitis who presented at the Ewha Womans University Medical Center (during 1999–2012) and the National Cancer Center (during 2005–2014) with only sensory symptoms as frst clinical features were enrolled in this study. Teir medical records, electrophysiological and laboratory data, and MRI fndings were analyzed retrospectively.
Results Of a total of 341 acute myelitis patients, 52 (15%) were identifed as having acute sensory myelitis. Te male-to-female ratio of these patients was 35:17, and their age at the onset of the condition was 41.7±10.5 years (mean±SD; range, 24–72 years). Acute sensory myelitis developed in patients with multiple sclerosis (MS; 14%), neuromyelitis optica spectrum disorder (NMOSD; 17%), and acute myelitis associated with concurrent systemic diseases including Behçet’s disease and cancer (6%). Despite detailed evaluation, the etiology of 33 patients with acute myelitis could not be determined. Longitudinally extensive transverse myelitis on spinal MRI and progression of the sensory level were observed most commonly in NMOSD patients (89% and 78%, respectively); however, these patients did not exhibit sensory dissociation. Residual negative sensory symptoms were observed more frequently in NMOSD patients (33%) than in those with acute myelitis of unknown cause (24%) or MS (14%). During the long-term follow-up (4.7±2.7 years) of patients who did not undergo maintenance immunotherapy, a monophasic clinical course was common in those with acute myelitis of unknown cause (76%), but not in NMOSD or MS patients.
Conclusions Accurate identifcation of the diverse nature of acute sensory myelitis may assist in patient care.
목차
등록된 정보가 없습니다.
참고문헌 (12)
참고문헌 신청
Freedman MS / 2005 / Recommended standard of cerebrospinal fluid analysis in the diagnosis of multiple sclerosis: a consensus statement / Arch Neurol 62 : 865 ~ 870
Frohman EM / 2010 / Clinical practice. Transverse myelitis / N Engl J Med 363 : 564 ~ 572
Jarius S / 2010 / Standardized method for the detection of antibodies to aquaporin-4 based on a highly sensitive immunofluorescence assay employing recombinant target antigen
Kim W / 2012 / Quantitative measurement of anti-aquaporin-4 antibodies by enzyme-linked immunosorbent assay using purified recombinant human aquaporin-4 / Mult Scler 18 : 578
Kira J / 1997 / Acute myelitis associated with hyperIgEemia and atopic dermatitis / J Neurol Sci 148 : 199 ~ 203
Frohman EM / 2010 / Clinical practice. Transverse myelitis / N Engl J Med 363 : 564 ~ 572
Jarius S / 2010 / Standardized method for the detection of antibodies to aquaporin-4 based on a highly sensitive immunofluorescence assay employing recombinant target antigen
Kim W / 2012 / Quantitative measurement of anti-aquaporin-4 antibodies by enzyme-linked immunosorbent assay using purified recombinant human aquaporin-4 / Mult Scler 18 : 578
Kira J / 1997 / Acute myelitis associated with hyperIgEemia and atopic dermatitis / J Neurol Sci 148 : 199 ~ 203
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