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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
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- 대한소아알레르기호흡기학회 Allergy Asthma & Respiratory Diseases Allergy Asthma & Respiratory Diseases 제3권 제4호
- 발행연도
- 2015.1
- 수록면
- 297 - 301 (5page)
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For the treatment of multidrug-resistant (MDR) tuberculosis, maintenance of appropriate antituberculous agents is essential because of its low cure rate and high dropout rate. Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a severe drug-induced systemic hypersensitivity response resulting in cessation of causative agents. In cases of second-line antituberculous agent-induced DRESS, it is extremely difficult to find other replacement medications to cure MDR tuberculosis. A 53-year-old male who had taken the second-line antituberculous agents (cycloserine, streptomycin, p-aminosalicylic acid, and prothionamide) as well as pyrazinamide for 5 weeks experienced DRESS syndrome accompanying hepatic coma. His symptoms improved with discontinuation of antituberculous agents and administration of high-dose methylprednisolone for 1 month. To resume the antituberculous medication, second-line antituberculous agents were administered one by one using a rapid desensitization protocol. While kanamycin, levofloxacin, and cycloserine were successfully readministered, p-aminosalicylic acid- and prothionamide-induced cutaneous hypersensitivity symptoms were relatively mild compared to previous reactions. Herein, we report a case of successfully treated MDR tuberculosis having a history of fatal DRESS syndrome to antituberculous agents using the rapid desensitization protocol.
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참고문헌 (12)
참고문헌 신청
World Health Organization / Global tuberculosis report 2013
김희진 / 2012 / 한국에서의 결핵현황 / 대한내과학회지 82(3):257~262
Kim DH / 2008 / Treatment outcomes and long-term survival in patients with extensively drug-resistant tuberculosis / Am J Respir Crit Care Med 178:1075~1082
Walsh SA / 2011 / Drug reaction with eosinophilia and systemic symptoms(DRESS) : a clinical update and review of current thinking / Clin Exp Dermatol 36:6~11
Cacoub P / 2011 / The DRESS syndrome : a literature review / Am J Med 124:588~597
김희진 / 2012 / 한국에서의 결핵현황 / 대한내과학회지 82(3):257~262
Kim DH / 2008 / Treatment outcomes and long-term survival in patients with extensively drug-resistant tuberculosis / Am J Respir Crit Care Med 178:1075~1082
Walsh SA / 2011 / Drug reaction with eosinophilia and systemic symptoms(DRESS) : a clinical update and review of current thinking / Clin Exp Dermatol 36:6~11
Cacoub P / 2011 / The DRESS syndrome : a literature review / Am J Med 124:588~597
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