지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아알레르기호흡기학회 Allergy Asthma & Respiratory Diseases Allergy Asthma & Respiratory Diseases 제3권 제2호
- 발행연도
- 2015.1
- 수록면
- 99 - 104 (6page)
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Purpose: Dysregulated cysteinyl leukotriene (CysLT) synthesis is prominent in exercise-induced bronchoconstriction (EIB). Secreted phospholipase A2 (sPLA2) plays a key regulatory role in the biosynthesis of CysLTs. We previously found that serum leptin levels correlate with (EIB) in children with asthma. The aim of this study was to address the relationship between plasma sPLA2/leptin levels and EIB.
Methods: Sixty-seven prepubertal children between the ages of 6 and 10 years were included in the study. They were asthmatics with EIB (n=25), asthmatics without EIB (n=21), and healthy subjects (n=21). We measured the plasma sPLA2 and leptin levels. We also performed pulmonary function tests at baseline, after bronchodilator inhalation, and after exercise.
Results: The sPLA2 and leptin levels were significantly higher in asthmatics with EIB than in those without and control subjects. In addition, sPLA2 levels were significantly correlated with body mass index (Speraman correlation coefficient r=0.343, P=0.023) and leptin levels (partial correlation coefficient r=318, P=0.033). The maximum decrease in % forced expiratory volume in 1 second after exercise was significantly correlated with both PLA2 levels (r=0.301, P=0.041) and leptin levels (r=0.346, P=0.018).
Conclusion: The sPLA2 and leptin levels were significantly higher in asthmatics with EIB than in asthmatics without EIB and control subjects. In addition, sPLA2 levels were significantly correlated with leptin levels and EIB in asthmatic children.
목차
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참고문헌 (22)
참고문헌 신청
American Thoracic Society / 2005 / ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and n
Back M / 2007 / 5-Lipoxygenase-activating protein : a potential link between innate and adaptive immunity in atherosclerosis and adipose tissue inflammation / Circ Res 100 :
Baek HS / 2011 / Serum leptin and adiponectin levels correlate with exercise-induced bronchoconstriction in children with asthma / Ann Allergy Asthma Immunol 107 : 14 ~ 21
Baek HS / 2013 / Leptin and urinary leukotriene E4 and 9α,11β-prostaglandin F2 release after exercise challenge / Ann Allergy Asthma Immunol 111 : 112 ~ 117
Bateman ED / 2008 / Global strategy for asthma management and prevention : GINA executive summary / Eur Respir J 31 : 143 ~ 178
Back M / 2007 / 5-Lipoxygenase-activating protein : a potential link between innate and adaptive immunity in atherosclerosis and adipose tissue inflammation / Circ Res 100 :
Baek HS / 2011 / Serum leptin and adiponectin levels correlate with exercise-induced bronchoconstriction in children with asthma / Ann Allergy Asthma Immunol 107 : 14 ~ 21
Baek HS / 2013 / Leptin and urinary leukotriene E4 and 9α,11β-prostaglandin F2 release after exercise challenge / Ann Allergy Asthma Immunol 111 : 112 ~ 117
Bateman ED / 2008 / Global strategy for asthma management and prevention : GINA executive summary / Eur Respir J 31 : 143 ~ 178
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