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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아알레르기호흡기학회 Allergy Asthma & Respiratory Diseases Allergy Asthma & Respiratory Diseases 제3권 제6호
- 발행연도
- 2015.1
- 수록면
- 439 - 445 (7page)
이용수
초록· 키워드
오류제보하기
Purpose: Fractional exhaled nitric oxide (FeNO) is useful for the diagnosis of allergic rhinitis (AR) as well as bronchial asthma (BA). However, FeNO may differ according to race, age, and other determinants. There have been few studies about FeNO in Korean children with AR. The aims of this study were to evaluate the value of FeNO in AR and to compare FeNO, and determinants of FeNO levels between AR, BA, and combined AR and BA.
Methods: This study included 647 children aged 5 to 17. The children were classified into 5 groups after performing the skin test, FeNO measurement, the pulmonary function test, and the methacholine challenge test: those with nonallergic rhinitis (NAR), those with AR, those with BA, and those with combined AR and BA, and healthy controls,.
Results: The values of FEV1 (forced expiratory volume in one second) %predicted were 94.4%±12.6%, 93.8%±20.7%, 90.0%±17.4% in AR, BA, and combined AR and BA, respectively. The values of FeNO in AR (32.3±25.0 ppb), BA (31.1±20.5 ppb), and combined AR and BA (34.5±30.4 ppb) were significantly higher compared to those of NAR (16.8±13.5 ppb) and controls (15.9±12.5 ppb). There was no significant difference in FeNO among AR, BA, and combined AR and BA. FeNO was significantly higher in patients with ≥4 positive results (36.6±29.2 ppb) than in those with <4 positive skin test results (27.6±20.7 ppb). When the receiver operating characteristic curve analysis for prediction of AR showed 0.756 of area under the curve, the cutoff level of FeNO was 16 ppb.
Conclusion: In this study, children with AR had increased levels of FeNO. It is suggested that AR may have eosinophilic bronchial inflammation without BHR or clinical asthma.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
American Thoracic Society / 2005 / ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and n
Bousquet J / 2008 / Togias A, Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen) / All
Chawes BL / 2010 / Children with allergic and nonallergic rhinitis have a similar risk of asthma / J Allergy Clin Immunol 126 : 567 ~ 573.e1-8
Ciprandi G / 2010 / Exhaled nitric oxide in children with allergic rhinitis and/or asthma : a relationship with bronchial hyperreactivity / J Asthma 47 : 1142 ~ 1147
Cobos Barroso N / 2008 / Exhaled nitric oxide in children : a noninvasive marker of airway inflammation / Arch Bronconeumol 44 : 41 ~ 51
Bousquet J / 2008 / Togias A, Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen) / All
Chawes BL / 2010 / Children with allergic and nonallergic rhinitis have a similar risk of asthma / J Allergy Clin Immunol 126 : 567 ~ 573.e1-8
Ciprandi G / 2010 / Exhaled nitric oxide in children with allergic rhinitis and/or asthma : a relationship with bronchial hyperreactivity / J Asthma 47 : 1142 ~ 1147
Cobos Barroso N / 2008 / Exhaled nitric oxide in children : a noninvasive marker of airway inflammation / Arch Bronconeumol 44 : 41 ~ 51
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