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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제36권 제2호
- 발행연도
- 2002.1
- 수록면
- 100 - 105 (6page)
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초록· 키워드
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Germline mutations in the breast cancer-associated genes BRCA1 and
BRCA2 confer susceptibility and a lifetime risk of breast cancer. Several morphological and clinical features have been attributed to hereditary tumors. However, in sporadic breast cancer, the interrelationship between the loss of heterozygosity (LOH) of these loci and clinical features remains to be fully elucidated. Methods : Microdissected paraffin-embedded tissue blocks of 48 cases of surgically resected breast carcinoma were investigated to identify the LOH of BRCA1 and BRCA2 using microsatellite markers. Results : Of 48 cases, 22 (45.9%)
exhibited LOH at BRCA1 locus while in 29 out of 48 (60.4%) cases LOH was observed for the BRCA2 region. There was no significant correlation betweeen LOH at BRCA1/2 and the patient’s age, tumor size, histologic grade or lymph node metastasis. When comparing the
frequency of LOH with the expression of several prognostic factors, such as p53, c-erb B2
protein, estrogen and progesterone receptor using immunohistochmeical stain, there was only correlation with LOH at BRCA2 and the progesterone receptor. Conclusions : Our results suggest that allelic deletion play a role to the development of sporadic breast cancers.
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