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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제43권 제6호
- 발행연도
- 2009.1
- 수록면
- 535 - 541 (7page)
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초록· 키워드
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Background : Differentiation of viral hepatitis from acute cellular rejection (ACR) after liver transplantation can be difficult because of overlapping histological features. Here we investigated clinicopathologic characteristics of 311 liver allograft biopsies and searched for characteristic
histopathological features that would facilitate the differential diagnosis between hepatitis B virus (HBV) infection and ACR. Methods : A retrospective clinicopathologic examination of 311 liver allograft biopsies consisting of clinically proven ACR or HBV infection was performed. Immunohistochemical staining for HBcAg and HBsAg was done for 64 allograft biopsies showing HBV infection. Results : Moderate to severe bile duct damage, diffuse centrilobular necrosis and centrilobular inflammation (p<0.000, for each) were more frequently observed in cases of ACR, whereas diffuse acidophilic bodies and spotty necrosis (p<0.000, for each) were more prevalent in cases of HBV infection. Immunopositivity for HBcAg (n=60, 93.8%) was higher than that for HBsAg (n=14, 21.9%). Conclusions : The presence of moderate
to severe bile duct damage, diffuse centrilobular necrosis and centrilobular inflammation was a characteristic feature of ACR, whereas diffuse distribution of acidophilic bodies or spotty necrosis was the only characteristic feature of HBV infection. HBcAg was a more sensitive immunohistochemical marker than HBsAg for detecting HBV infection in liver allograft biopsies.
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등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Chen CL / 2003 / Living-donor liver transplantation: 12 years of experience in Asia / Transplantation 75 : S6 ~ S11
Demetris AJ / 1986 / Recurrent hepatitis B in liver allograft recipients. Differentiation between viral hepatitis B and rejection / Am J Pathol 125 : 161 ~ 172
Demetris AJ / 1990 / Evolution of hepatitis B virus liver disease after hepatic replacement. Practical and theoretical considerations / Am J Pathol 137 : 667 ~ 676
Demetris AJ / 1997 / Banff schema for grading liver allograft rejection: an international consensus document / Hepatology 25 : 658 ~ 663
Demetris AJ / 2002 / Real-time monitoring of acute liver-allograft rejection using the Banff schema / Transplantation 74 : 1290 ~ 1296
Demetris AJ / 1986 / Recurrent hepatitis B in liver allograft recipients. Differentiation between viral hepatitis B and rejection / Am J Pathol 125 : 161 ~ 172
Demetris AJ / 1990 / Evolution of hepatitis B virus liver disease after hepatic replacement. Practical and theoretical considerations / Am J Pathol 137 : 667 ~ 676
Demetris AJ / 1997 / Banff schema for grading liver allograft rejection: an international consensus document / Hepatology 25 : 658 ~ 663
Demetris AJ / 2002 / Real-time monitoring of acute liver-allograft rejection using the Banff schema / Transplantation 74 : 1290 ~ 1296
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