De Novo Superinfection of Hepatitis B Virus in an Anti-HBs Positive Patient with Recurrent Hepatitis C Following Liver Transplantation

하승혜; Young Min Park; Sun-Pyo Hong; So-Ya Back; Soo-Kyeong Shin; Seung-Il Ji; Soo-Ok Kim; Wang-don Yoo; Bo-Hyun Kim; Sang-Jong Park; Zheng Hong

추천

검색

자료유형: 학술저널

저자정보: 하승혜 Young Min Park Sun-Pyo Hong So-Ya Back Soo-Kyeong Shin Seung-Il Ji Soo-Ok Kim Wang-don Yoo Bo-Hyun Kim Sang-Jong Park Zheng Hong

저널정보: 거트앤리버 발행위원회 Gut and Liver Gut and Liver 제5권 제2호

발행연도: 2011.1

수록면: 248 - 252 (5page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

A 60-year-old woman with end stage liver cirrhosis caused by genotype 2 hepatitis C virus (HCV) infection received an orthotopic liver transplantation (OLT). The patient was negative for the hepatitis B surface antigen (HBsAg) and positive for the anti-hepatitis B surface antibody (anti-HBs) prior to and one and a half months following the OLT. Due to reactivation of hepatitis C, treatment with interferon-alpha and Ribavirin started two months following the OLT and resulted in a sustained virological response. We performed a liver biopsy because a biochemical response was not achieved. Surprisingly,liver pathology showed HBsAg-positive hepatocytes with a lobular hepatitis feature, which had been negative in the liver biopsy specimen obtained one and a half months post-OLT. High titers of both HBsAg and HBeAg were detected,while anti-HBs antibodies were not found. Tests for IgM antihepatitis B core antibody and anti-delta virus antibodies were negative. The serum HBV DNA titer was over 1×10^7 copies/mL. A sequencing analysis showed no mutation in the “a”determinant region, but revealed a mixture of wild and mutant strains at an overlapping region of the S and P genes (S codon 213 (Leu/Ile); P codons 221 (Phe/Tyr) and 222 (Ala/Thr)). These findings suggest that de novo hepatitis B can develop in patients with HCV infection during the post-OLT period despite the presence of protective anti-HBs.

#De novo hepatitis B virus infection #Occult hepatitis B virus infection #Post-orthotopic liver transplantation recurrent hepatitis C #Orthotopic liver transplantation

참고문헌 (14)

참고문헌 신청

Allain JP / 2004 / Occult hepatitis B virus infection / Transfus Clin Biol 11 : 18 ~ 25

Barcena R / 2006 / Prevention of de novo HBV infection by the presence of anti-HBs in transplanted patients receiving core antibody-positive livers / World J Gastroenterol 12

Coffin CS / 2007 / Profound suppression of chronic hepatitis C following superinfection with hepatitis B virus / Liver Int 27 : 722 ~ 726

Dodson SF / 1997 / Infectivity of hepatic allografts with antibodies to hepatitis B virus / Transplantation 64 : 1582 ~ 1584

Joya-Vazquez PP / 2002 / Impact of antihepatitis Bc-positive grafts on the outcome of liver transplantation for HBV-related cirrhosis / Transplantation 73 : 1598 ~ 1602