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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제43권 제6호
- 발행연도
- 2009.1
- 수록면
- 542 - 549 (8page)
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초록· 키워드
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Background : Aberration of the cell cycle regulatory proteins has been reported to contribute to the development and progression of human malignancy. We studied the expression of G1/S cell cycle regulatory proteins to investigate the carcinogenesis in cutaneous squamous cell lesions. Methods : We evaluated the expressions of p16, pRb, cyclin D1 and Ki-67 protein by immunonohistochemistry in cases of normal skin (n=15), seborrheic keratosis (SK; n=26), actinic keratosis (AK; n=30), Bowen’s disease (BD; n=37), keratoacanthoma (KA; n= 23), and squamous cell carcinoma (SCC; n=22). Results : The Ki-67 expression gradually increased from SK, through AK, to BD. The expression of p16 was more increased in BD than
that in AK. The decreased expressions of p16 and Rb, and the increased expression of cyclin D1 were observed to a greater degree in SCC than those in BD. The expressions of cyclin D1 and Ki-67 were higher in SCC than those in KA. Conclusions : The altered expressions of p16, Rb, and cyclin D1 were considered to be related to the carcinogenesis in the cutaneous squamous cell lesions. Therefore, immunohistochemical studies of the cell
cycle regulatory proteins and a combined analysis may be helpful as an adjunct to the histomorphology in the diagnosis of cutaneous squamous cell lesions.
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참고문헌 (25)
참고문헌 신청
Baum HP / 1994 / Expression of proliferation-associated proteins (proliferating cell nuclear antigen and Ki-67 antigen) in Bowen’s disease / Br J Dermatol 131 : 231 ~ 236
Bianchi AB / 1993 / Overexpression of cyclin D1 in mouse skin carcinogenesis / Oncogene 8 : 1127 ~ 1133
Brown DC / 1990 / Monoclonal antibody Ki-67: its use in histopathology / Histopathology 17 : 489 ~ 503
Brown VL / 2004 / p16INK4a and p14ARF tumor suppressor genes are commonly inactivated in cutaneous squamous cell carcinoma / J Invest Dermatol 122 : 1284 ~ 1292
Burnworth B / 2007 / The multi-step process of human skin carcinogenesis: a role for p53, cyclin D1, hTERT, p16, and TSP-1 / Eur J Cell Biol 86 : 763 ~ 780
Bianchi AB / 1993 / Overexpression of cyclin D1 in mouse skin carcinogenesis / Oncogene 8 : 1127 ~ 1133
Brown DC / 1990 / Monoclonal antibody Ki-67: its use in histopathology / Histopathology 17 : 489 ~ 503
Brown VL / 2004 / p16INK4a and p14ARF tumor suppressor genes are commonly inactivated in cutaneous squamous cell carcinoma / J Invest Dermatol 122 : 1284 ~ 1292
Burnworth B / 2007 / The multi-step process of human skin carcinogenesis: a role for p53, cyclin D1, hTERT, p16, and TSP-1 / Eur J Cell Biol 86 : 763 ~ 780
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