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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제44권 제6호
- 발행연도
- 2010.1
- 수록면
- 571 - 580 (10page)
이용수
초록· 키워드
오류제보하기
Background : Colorectal cancer (CRC) is one of the most common malignant neoplasms and is a leading cause of mortality worldwide. Metastasis to the liver is a frequent event in patients with CRC. An essential step in the metastatic cascade is angiogenesis. Methods : This study included 45 patients who underwent a partial colectomy with hepatic resection for CRC with hepatic metastases. Immunohistochemistry was performed using vascular endothelial growth factor (VEGF)-A, VEGF receptor (VEGFR)-1, VEGFR-2, and CD34 antibodies to examine the relationship between CRC with liver metastases and angiogenesis. Results : CRC showed significantly stronger expression of VEGF-A, VEGFR-1, and VEGFR-2 than liver metastases (p < 0.05). Microvessel density was also higher in CRC than in liver metastases (p < 0.05). Conclusions : Compared with previous studies, we found a higher expression of VEGF-A, VEGFR-1, VEGFR-2, and microvessel density in CRC than in liver metastases, which could be ascribed to a difference in vessel distribution and blood supply in each organ. Given its profuse blood supply and distinct cell populations, the liver might provide a rich milieu for tumor cell growth with less expression of angiogenesis-inducing agents.
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참고문헌 (24)
참고문헌 신청
Beckner ME / 1999 / Factors promoting tumor angiogenesis / Cancer Invest 17 : 594 ~ 623
Bird NC / 2006 / Biology of colorectal liver metastases:a review / J Surg Oncol 94 : 68 ~ 80
Bosari S / 1992 / Microvessel quantitation and prognosis in invasive breast carcinoma / Hum Pathol 23 : 755 ~ 761
Cascinu S / 2000 / Differences of vascular endothelial growth factor(VEGF)expression between liver and abdominal metastases from colon cancer:implications for the treatment
Dachs GU / 1998 / Microenvironmental control of gene expression:implications for tumor angiogenesis,progression,and metastasis / Semin Radiat Oncol 8 : 208 ~ 216
Bird NC / 2006 / Biology of colorectal liver metastases:a review / J Surg Oncol 94 : 68 ~ 80
Bosari S / 1992 / Microvessel quantitation and prognosis in invasive breast carcinoma / Hum Pathol 23 : 755 ~ 761
Cascinu S / 2000 / Differences of vascular endothelial growth factor(VEGF)expression between liver and abdominal metastases from colon cancer:implications for the treatment
Dachs GU / 1998 / Microenvironmental control of gene expression:implications for tumor angiogenesis,progression,and metastasis / Semin Radiat Oncol 8 : 208 ~ 216
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