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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제44권 제6호
- 발행연도
- 2010.1
- 수록면
- 642 - 650 (9page)
이용수
초록· 키워드
오류제보하기
Background : Pathologists occasionally have difficulty in distinguishing cholangiocarcinoma from benign reactive cells on the biliary cytology. We estimated the diagnostic value of insulinlike growth factor II mRNA binding protein 3 (IMP3) on biliary cytology specimens. Methods : We selected 40 patients who had undergone a biliary cytology examination and whose diagnoses were confirmed by biopsy. The IMP3 expression was evaluated by immunohistochemical staining in both the tissue and the cytology specimens. Their histologic diagnoses were cholangiocarcinoma (n = 34), high grade dysplasia (n = 2), low grade dysplasia (n = 1) and non-biliary tumor or no tumor (n = 3). Results : On the histology, all the cases of cholangiocarcinoma or high grade dysplasia were positive for IMP3 (36/36). The low grade dysplasia or the normal bile ducts in the other 4 cases were negative for IMP3 (0/4). Of the 36 cases diagnosed as cholangiocarcinoma or high grade dysplasia histologically, 29 cases were positive for IMP3 on the cytology (29/36; sensitivity, 80.6%). Of the 4 cases without cholangiocarcinoma or high grade dysplasia, 1 case was weakly positive for IMP3 on the cytology. The histologic diagnosis of this case was hepatocellular carcinoma. Except for this hepatocellular carcinoma case, the specificity of IMP3 on the cytology was 100%. Conclusions : IMP3 is a useful diagnostic marker for cholangiocarcinoma on cytology.
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등록된 정보가 없습니다.
참고문헌 (19)
참고문헌 신청
Findeis-Hosey JJ / 2010 / IMP3 expression is correlated with histologic grade of lung adenocarcinoma / Hum Pathol 41 : 477 ~ 484
Hamilton SR / 2000 / World Health Organization classification of tumors: pathology and genetics of tumors of the digestive systems / IARC Press : 158 ~ 214
Ikeda K / 2010 / IMP3/L523S,a novel immunocytochemical marker that distinguishes benign and malignant cells:the expression profiles of IMP3/L523S in effusion cytology / Hum
Jeng YM / 2008 / RNA-binding protein insulin-like growth factor II mRNA-binding protein 3 expression promotes tumor invasion and predicts early recurrence and poor prognosis
Jiang Z / 2008 / Combination of quantitative IMP3 and tumor stage:a new system to predict metastasis for patients with localized renal cell carcinomas / Clin Cancer Res 14 :
Hamilton SR / 2000 / World Health Organization classification of tumors: pathology and genetics of tumors of the digestive systems / IARC Press : 158 ~ 214
Ikeda K / 2010 / IMP3/L523S,a novel immunocytochemical marker that distinguishes benign and malignant cells:the expression profiles of IMP3/L523S in effusion cytology / Hum
Jeng YM / 2008 / RNA-binding protein insulin-like growth factor II mRNA-binding protein 3 expression promotes tumor invasion and predicts early recurrence and poor prognosis
Jiang Z / 2008 / Combination of quantitative IMP3 and tumor stage:a new system to predict metastasis for patients with localized renal cell carcinomas / Clin Cancer Res 14 :
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