지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제45권 제4호
- 발행연도
- 2011.1
- 수록면
- 379 - 385 (7page)
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초록· 키워드
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Background: Recent studies have demonstrated that insulin-like growth factor II mRNA-binding protein 3 (IMP3) is expressed in malignant tumors of various organs but not in normal tissue. We investigated IMP3 expression in various benign lesions, premalignant lesions and carcinomas of the stomach. Methods: IMP3 immunohistochemical staining was performed on 24 benign gastric lesions, 24 gastric adenomas, and 322 gastric carcinomas. Results: IMP3 was not expressed in benign gastric lesions including adenomas with low-grade dysplasia, but was expressed in 17% of adenomas with high-grade dysplasia, and in 44% of carcinomas. As the carcinomas were in the advanced stage, they expressed IMP3 more frequently and strongly. Patients with IMP3-positive tumors had poorer survival than those with negative tumors. Conclusions: IMP3 expression in gastric carcinoma may be related to tumor invasion and metastasis, and is an independent risk factor for poor prognosis.
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참고문헌 (27)
참고문헌 신청
Greene FL / 2002 / AJCC cancer staging manual. 6th ed / Springer-Verlag :99~103
Yaniv K / 2002 / The involvement of a conserved family of RNA binding proteins in embryonic development and carcinogenesis / Gene 287:49~54
Vikesaa J / 2006 / RNA-binding IMPs promote cell adhesion and invadopodia formation / EMBO J 25:1456~1468
Nemunaitis J / 2006 / Phase I Trial of sequential administration of recombinant DNA and adenovirus expressing L523S protein in early stage non-small-cell lung cancer / Mol Ther 13:1185~1191
Bang YJ / 2010 / Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer
Yaniv K / 2002 / The involvement of a conserved family of RNA binding proteins in embryonic development and carcinogenesis / Gene 287:49~54
Vikesaa J / 2006 / RNA-binding IMPs promote cell adhesion and invadopodia formation / EMBO J 25:1456~1468
Nemunaitis J / 2006 / Phase I Trial of sequential administration of recombinant DNA and adenovirus expressing L523S protein in early stage non-small-cell lung cancer / Mol Ther 13:1185~1191
Bang YJ / 2010 / Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer
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