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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제37권 제4호
- 발행연도
- 2003.1
- 수록면
- 282 - 286 (5page)
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Primary nodal marginal zone B-cell lymphoma (MZBCL) is recognized as a rare and distinct entity. The rate of histologic transformation into diffuse large B-cell lymphoma (DLBCL) seems lower than the rate of transformation in follicular lymphoma. We herein report a rare case of nodal MZBCL showing transformation into DLBCL. The patient was a 73-year-old female with cervical lymphadenopathy. On the initial biopsy, the lymph node architecture was diffusely
effaced with an extensive interfollicular and parafollicular infiltrate of monocytoid B-cells. There were scattered large blastic B-cells without formations of compact sheets. The diagnosis of
nodal MZBCL was made. The patient did not receive chemotherapy and was treated with a conservatively supportive regimen. Forty two months later, the patient developed a new cervical lymphadenopathy and a biopsy was performed. Histologically, the lymph node revealed diffuse sheets of transformed large B-cells showing prominent nucleoli. The diagnosis of
DLBCL transformed from nodal MZBCL was made. The patient was treated with 3 cycles of combined CHOP chemotherapy and she showed clinical improvement. These observations suggest that an untreated primary nodal MZBCL may undergo high-grade transformation.
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