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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제37권 제4호
- 발행연도
- 2003.1
- 수록면
- 270 - 278 (9page)
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초록· 키워드
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Background : Mucin producing cystic neoplasms, such as mucinous cystic tumor (MCT) and intraductal papillary mucinous tumor (IPMT) of the pancreas, are uncommon but become increasing in their incidences. The pathologic classification and biologic potential of these neoplasms
remain the subject of controversy. Methods : The Gastrointestinal Pathology Study Group of
the Korean Society of Pathologists analyzed the clinicopathologic characteristics of 85 cases
of MCT and 72 cases of IPMT and examined the expression patterns of p53, CEA and MUC1.
Results : IPMT was located largely in the head, and showed connection with the main pancreatic
duct (MPD, 68.1%), no ovarian-like stroma (0/72), and presence of intervening intratumoral
normal or atrophic parenchyma. On the other hand, MCT was located largely in the
tail (73%), and showed common ovarian-like stroma (66/80), rare connection with the MPD
(7/85) and no intervening pancreatic parenchyma. CEA and p53 immunoexpressions were
significantly increased from adenoma through borderline to carcinoma, but MUC 1 was expressed
only in the invasive carcinoma among cases of MCT and IPMT. Conclusions : The tumor
location, ovarian-like stroma, connection with the MPD and intratumoral intervening nonneoplastic
tissue were helpful in the differential diagnosis between IPMT and MCT. CEA and p53
expressions can be indicators of malignancy, while MUC 1 expression can indicate invasion.
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