지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.6
- 수록면
- 436 - 442 (7page)
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초록· 키워드
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Purpose: Intraductal papillary mucinous tumor (IPMT) of the pancreas pathologically shows papillary proliferation and its tumor cells display a spectrum of changes ranging from adenoma to infiltrating carcinoma. Because of this variability, there have been many difficulties for making an accurate diagnosis and administering proper treatment. The aim of this study was to determine the treatment strategy and differential diagnosis of benign and malignant IPMT.
Methods: Between January 2000 and June 2007, 24 patients with IPMT of the pancreas underwent surgery. The relationships among the clinopathologic features and tumor locations and subtypes were retrospectively investigated. In addition, the type of surgical procedures and findings, the microscopic finding, the immunohistochemical staining and the clinopathological features were analyzed.
Results: There were 17 men and 7 women with a mean age of 65 (range: 45∼81). Pathologically, 11 cases were benign, 9 were borderline and 4 were malignant. The tumor was located in the head of the pancreas in 17 patients. 16 cases received Whipple’s procedure and pylorus preserving pancreaticoduodenectomy, and the others were received different kinds of operations. Regarding the subtypes of IPMT, 2 cases were the main duct type, 19 were the branched type and 3 were the combined type. There were no statistically significant differences in the clinical manifestations, radiologic findings and immnohistochemical staining between the patients with benign and malignant IPMT. Except two patients who were not followed up, all the patients had no recurrence and they survived.
Conclusion: It is very difficult to exactly differentiate malignant IPMT from benign IPMT with using the current preoperative evaluations and immunohistochemical staining of the resected specimens. The patients who were operated on and followed in our hospital had no recurrence and they all survived. Therefore, if IPMT is suspected, we think the patients should be operated on and we should continue studying other specific antibodies for immunohistochemical staining.
Methods: Between January 2000 and June 2007, 24 patients with IPMT of the pancreas underwent surgery. The relationships among the clinopathologic features and tumor locations and subtypes were retrospectively investigated. In addition, the type of surgical procedures and findings, the microscopic finding, the immunohistochemical staining and the clinopathological features were analyzed.
Results: There were 17 men and 7 women with a mean age of 65 (range: 45∼81). Pathologically, 11 cases were benign, 9 were borderline and 4 were malignant. The tumor was located in the head of the pancreas in 17 patients. 16 cases received Whipple’s procedure and pylorus preserving pancreaticoduodenectomy, and the others were received different kinds of operations. Regarding the subtypes of IPMT, 2 cases were the main duct type, 19 were the branched type and 3 were the combined type. There were no statistically significant differences in the clinical manifestations, radiologic findings and immnohistochemical staining between the patients with benign and malignant IPMT. Except two patients who were not followed up, all the patients had no recurrence and they survived.
Conclusion: It is very difficult to exactly differentiate malignant IPMT from benign IPMT with using the current preoperative evaluations and immunohistochemical staining of the resected specimens. The patients who were operated on and followed in our hospital had no recurrence and they all survived. Therefore, if IPMT is suspected, we think the patients should be operated on and we should continue studying other specific antibodies for immunohistochemical staining.
목차
서론
방법
결과
고찰
결론
REFERENCES
참고문헌 (29)
참고문헌 신청
Ohashi K , 1982 , Four case of “mucin- producing” cancer of pancreas on specific fingings of the papillary Vater , Prog Dig Endosc 20 : 348 ~ 351
Choi KY , 1992 , Primary pancreatic tumor. Analysis of 181 cases according to the revised pathologic classification , Korean J Gastroenterol 24 : 354 ~ 365
Cellier C , 1998 , Intraductal papillary and mucinous tumors of the pancreas: accuracy of preoperative computed tomography, endoscopic retrograde pancreatography and endoscopic ultrasonography, and long-term outcome in a large surgical series , Gastrointest Endosc 47 : 42 ~ 49
Chang JY , 2006 , 췌장의 낭성 종양. 간담췌외과학, 2판 , 의학문화사 : 877 ~ 878
Yamaguchi K , 2001 , Intraductal papillary-mucinous tumor of pancreas:a Historical review of the nomenclature and recent controversy , Pancreas 23 : 12 ~ 19
Choi KY , 1992 , Primary pancreatic tumor. Analysis of 181 cases according to the revised pathologic classification , Korean J Gastroenterol 24 : 354 ~ 365
Cellier C , 1998 , Intraductal papillary and mucinous tumors of the pancreas: accuracy of preoperative computed tomography, endoscopic retrograde pancreatography and endoscopic ultrasonography, and long-term outcome in a large surgical series , Gastrointest Endosc 47 : 42 ~ 49
Chang JY , 2006 , 췌장의 낭성 종양. 간담췌외과학, 2판 , 의학문화사 : 877 ~ 878
Yamaguchi K , 2001 , Intraductal papillary-mucinous tumor of pancreas:a Historical review of the nomenclature and recent controversy , Pancreas 23 : 12 ~ 19
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