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자료유형
학술저널
저자정보
저널정보
대한내과학회 대한내과학회지 대한내과학회지 제79권 제4호
발행연도
2010.1
수록면
381 - 386 (6page)

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Background/Aims: Considerable evidence indicates that patients with chronic hepatitis C virus (HCV) infection have a greater risk of developing insulin resistance (IR) compared with non-infected individuals or patients with hepatitis B virus (HBV) infection. Few reports have examined the prevalence of IR and hepatic steatosis in patients with chronic HCV infection in Korea. Methods: Ninety subjects positive for HCV antibody who had normal fasting blood glucose levels and no history of diabetes mellitus were compared with 271 HCV non-infected, age- and sex-matched, healthy examinees between January 2005 and December 2006. Results: No significant differences in the body mass index (BMI) and fasting blood glucose level were found between the anti- HCV-antibody-positive and non-infected groups. The serum fasting insulin level was significantly higher in the HCV-antibody-positive group than in the non-infected group (9.11±2.94 vs. 8.43±2.70 µU/mL (mean±SD), p=0.04). Although the homeostasis model assessment of insulin resistance (HOMA-IR) was not significantly different between the two groups (2.035±0.69 vs. 1.899±0.64, p=0.088), the prevalence of insulin resistance (HOMA-IR≥2.7) was significantly higher in the anti-HCV positive group (18.9% vs. 10.3%, p=0.042). Hepatic steatosis identified by transabdominal ultrasonography was significantly more frequent in the non-infected group (20.3% vs. 11.1%, p=0.028). Conclusions: The anti-HCV positive subjects had significant hyperinsulinemia and a higher prevalence of insulin resistance than the non-infected group, whereas hepatic steatosis was more frequent in the non-infected group.

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