지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Background/Aims: Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reaction with eosinophilia andsystemic symptoms (DRESS) are severe cutaneous adverse reactions (SCARs) that also affect the internal organs with highmortality. However, there has been no previous nationwide study of SCARs in Korea.
Methods: Cases of SCARs were recruited from the nationwide Korean Pharmacovigilance Research Network database, collectedfrom June 2009 to December 2010, by a spontaneous reporting system. We analyzed age, gender, route of administration and thecausative agents. We also reviewed previously published cases of SCARs in Korea.
Results: In total, 100 cases of SJS (66 cases), TEN (7 cases), and DRESS (27 cases) were reported. The mean age of the patientswas 54.1 ± 19.8 years and the proportion of males to females was 1:0.88. In total, 81 drugs were reported as causative agents: SJS(61 drugs), TEN (15 drugs), and DRESS (29 drugs). The most commonly reported causative drug was allopurinol (12 cases).
Allopurinol (8 cases) and levofloxacin (2 cases) were the most commonly reported causative drugs for SJS and TEN, respectively.
In DRESS, allopurinol (4 cases) and vancomycin (4 cases) were the two most common causative drugs. Anti-infective drugs werethe most common drug category (75 cases). Carbamazepine was the most commonly reported causative drug according topublished cases in Korea.
Conclusions: Allopurinol in the spontaneous reporting system and carbamazepine in the published cases were the most commonsingle causative drugs in SCARs in Korea. Anti-infectives were the most common drug category in the spontaneous reportingsystem.
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참고문헌 (25)
참고문헌 신청
Barvaliya M / 2011 / Drug-induced Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS-TEN overlap: a multicentric retrospective study / J Postgrad Med
Cacoub P / 2011 / The DRESS syndrome: a literature review / Am J Med 124 : 588 ~ 597
Edwards IR / 2000 / Adverse drug reactions: definitions, diagnosis, and management / Lancet 356 : 1255 ~ 1259
Friedmann PS / 2003 / Mechanisms in cutaneous drug hypersensitivity reactions / Clin Exp Allergy 33 : 861 ~ 872
Hung SI / 2005 / HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol / Proc Natl Acad Sci USA 102 : 4134 ~ 4139
Cacoub P / 2011 / The DRESS syndrome: a literature review / Am J Med 124 : 588 ~ 597
Edwards IR / 2000 / Adverse drug reactions: definitions, diagnosis, and management / Lancet 356 : 1255 ~ 1259
Friedmann PS / 2003 / Mechanisms in cutaneous drug hypersensitivity reactions / Clin Exp Allergy 33 : 861 ~ 872
Hung SI / 2005 / HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol / Proc Natl Acad Sci USA 102 : 4134 ~ 4139
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