지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Hepatic encephalopathy, one of the major complications of cirrhosis, is a neuropsychiatric syndrome caused by accumulation of toxins in the central nervous system following dysfunction in liver detoxification. Various manifestations makes it difficulty to diagnose and categorize hepatic encephalopathy. For the consistency in diagnosis and staging of hepatic encephalopathy, standardized nomenclature regarding forms of hepatic encephalopathy was proposed recently. Due to the poor understanding of pathophysiology, effective prevention or treatment options are limited. Based on the theory that intestinal-derived ammonia plays major role in the development of hepatic encephalopathy, therapeutic approaches are directed at reducing intestinal bacterial production of ammonia and facilitating its elimination. Non-absorbable disaccharides, antibiotics such as rifaximin and L-ornithine-L-aspartate are main therapies for hepatic encephalopathy. Alternative therapies such as benzodiazepine receptor antagonists, branched-chain amino acids, sodium benzoate and acarbose have limited data supporting their use. Precipitating factors must be looked into carefully and corrected immediately because most patients are usually present with precipitating factors. Hepatic encephalopathy without precipitating factors shows poor prognosis and could be candidate of liver transplantation. (Korean J Med 75:27-36, 2008)
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Abou-Assi S / 2001 / Hepatic encephalopathy: metabolic consequence of cirrhosis often is reversible / Postgrad Med 109 : 52 ~ 70
Amodio P / 2001 / Prevalence and prognostic value of quantified electroencephalogram (EEG) alterations in cirrhotic patients / J Hepatol 35 : 37 ~ 45
Atterbury CE / 1978 / Neomycin-sorbitol and lactulose in the treatment of acute portal-systemic encephalopathy. A controlled, double-blind clinical trial / Am J Dig Dis 23 :
Blei AT / 2001 / Practice Parameters Committee of the American College of Gastroenterology. Hepatic encephalopathy / Am J Gastroenterol 96 : 1968 ~ 1976
Bustamante J / 1999 / Prognostic significance of hepatic encephalopathy in patients with cirrhosis / J Hepatol 30 : 890 ~ 895
Amodio P / 2001 / Prevalence and prognostic value of quantified electroencephalogram (EEG) alterations in cirrhotic patients / J Hepatol 35 : 37 ~ 45
Atterbury CE / 1978 / Neomycin-sorbitol and lactulose in the treatment of acute portal-systemic encephalopathy. A controlled, double-blind clinical trial / Am J Dig Dis 23 :
Blei AT / 2001 / Practice Parameters Committee of the American College of Gastroenterology. Hepatic encephalopathy / Am J Gastroenterol 96 : 1968 ~ 1976
Bustamante J / 1999 / Prognostic significance of hepatic encephalopathy in patients with cirrhosis / J Hepatol 30 : 890 ~ 895
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