지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 270 - 279 (10page)
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초록· 키워드
오류제보하기
Sarcopenia (loss of muscle mass and/or strength) frequently complicates liver cirrhosis and adversely affects the quality of life; cirrhosis related liver decompensation and significantly decreases wait-list and post-liver transplantation survival. The main therapeutic strategies to improve or reverse sarcopenia include dietary interventions (supplemental calorie and protein intake), increased physical activity (supervised resistance and endurance exercises), hormonal therapy (testosterone), and ammonia lowering agents (L-ornithine L-aspartate, branch chain amino acids) as well as mechanistic approaches that target underlying molecular and metabolic abnormalities. Besides other factors, hyperammonemia has recently gained attention and increase sarcopenia by various mechanisms including increased expression of myostatin, increased phosphorylation of eukaryotic initiation factor 2a, cataplerosis of α ketoglutarate, mitochondrial dysfunction, increased reactive oxygen species that decrease protein synthesis and increased autophagy-mediated proteolysis. Sarcopenia contributes to frailty and increases the risk of minimal and overt hepatic encephalopathy.
목차
등록된 정보가 없습니다.
참고문헌 (88)
참고문헌 신청
Cruz-Jentoft AJ / 2010 / Sarcopenia : European consensus on definition and diagnosis : report of the European working group on sarcopenia in older people / Age Ageing 39:412~423
Janssen I / 2010 / Evolution of sarcopenia research / Appl Physiol Nutr Metab 35:707~712
Montano-Loza AJ / 2014 / Clinical relevance of sarcopenia in patients with cirrhosis / World J Gastroenterol 20:8061~8071
Tandon P / 2012 / Severe muscle depletion in patients on the liver transplant wait list : its prevalence and independent prognostic value / Liver Transpl 18:1209~1216
Kim G / 2017 / Prognostic value of sarcopenia in patients with liver cirrhosis : a systematic review and meta-analysis / PLoS One 12:e0186990
Janssen I / 2010 / Evolution of sarcopenia research / Appl Physiol Nutr Metab 35:707~712
Montano-Loza AJ / 2014 / Clinical relevance of sarcopenia in patients with cirrhosis / World J Gastroenterol 20:8061~8071
Tandon P / 2012 / Severe muscle depletion in patients on the liver transplant wait list : its prevalence and independent prognostic value / Liver Transpl 18:1209~1216
Kim G / 2017 / Prognostic value of sarcopenia in patients with liver cirrhosis : a systematic review and meta-analysis / PLoS One 12:e0186990
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