지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 308 - 316 (9page)
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초록· 키워드
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Background: Several antibiotics can be used to treat ventilator-associated pneumonia caused by carbapenem-resistant A. baumannii (CRAB-VAP) including high-dose sulbactam. However, the effectiveness of high-dose sulbactam therapy is not well known. We report our experience with high-dose sulbactam for treatment of CRAB-VAP.
Methods: Medical records of patients with CRAB-VAP who were given high-dose sulbactam between May 2013 and June 2015 were reviewed.
Results: Fifty-eight patients with CRAB-VAP were treated with high-dose sulbactam. The mean age was 72.0 ± 15.2 years, and the acute physiology and chronic health evaluation II (APACHE II) score was 15.1 ± 5.10 at the time of CRAB-VAP diagnosis. Early clinical improvement was observed in 65.5% of patients, and 30-day mortality was 29.3%. Early clinical failure (odds ratio [OR]: 8.720, confidence interval [CI]: 1.346-56.484; p = 0.023) and APACHE II score ≥ 14 at CRAB-VAP diagnosis (OR: 10.934, CI: 1.047-114.148; p = 0.046) were associated with 30-day mortality.
Conclusions: High-dose sulbactam therapy may be effective for the treatment of CRAB-VAP. However, early clinical failure was observed in 35% of patients and was associated with poor outcome.
목차
등록된 정보가 없습니다.
참고문헌 (31)
참고문헌 신청
Dijkshoorn L / 2007 / An increasing threat in hospitals: multidrug-resistant Acinetobacter baumannii / Nat Rev Microbiol 5:939~951
Lortholary O / 1995 / Nosocomial acquisition of multiresistant Acinetobacter baumannii: risk factors and prognosis / Clin Infect Dis 20:790~796
Jawad A / 1996 / Influence of relative humidity and suspending menstrua on survival of Acinetobacter spp. on dry surfaces / J Clin Microbiol 34:2881~2887
Fournier PE / 2006 / The epidemiology and control of Acinetobacter baumannii in health care facilities / Clin Infect Dis 42:692~699
Castanheira M / 2014 / Update on Acinetobacter species: mechanisms of antimicrobial resistance and contemporary in vitro activity of minocycline and other treatment options / Clin Infect Dis 59(6):S367~S373
Lortholary O / 1995 / Nosocomial acquisition of multiresistant Acinetobacter baumannii: risk factors and prognosis / Clin Infect Dis 20:790~796
Jawad A / 1996 / Influence of relative humidity and suspending menstrua on survival of Acinetobacter spp. on dry surfaces / J Clin Microbiol 34:2881~2887
Fournier PE / 2006 / The epidemiology and control of Acinetobacter baumannii in health care facilities / Clin Infect Dis 42:692~699
Castanheira M / 2014 / Update on Acinetobacter species: mechanisms of antimicrobial resistance and contemporary in vitro activity of minocycline and other treatment options / Clin Infect Dis 59(6):S367~S373
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