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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 203 - 211 (9page)
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초록· 키워드
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The aim of this study was to evaluate the role of demineralized and particulate autogenous tooth, and interleukin-6 in bone regeneration.
A demineralized and particulate autogenous tooth was prepared and human osteoblast-like cells (MG63) and human osteosarcoma cells were inoculated into the culture. The rate of cell adhesion, proliferation and mineralization were examined, and the appearance of cellular attachment was observed. An 8 mm critical size defect was created in the cranium of rabbits. Nine rabbits were divided into three groups including: An experimental group A (3 rabbits), in which a demineralised and particulate autogenous tooth was grafted; an experimental group B (3 rabbits), in which a demineralized, particulate autogenous tooth was grafted in addition to interleukin-6 (20 ng/mL); and a control group.
The rabbits were sacrificed at 1, 2, 4 and 6 weeks for histopathological examination with H-E and Masson’s Trichrome, and immunohistochemistry with osteocalcin.
The cell-based assay showed a higher rate of cell adhesion, mineralization and cellular attachment in the experimental group A compared with the control group. The animal study revealed an increased number of osteoclasts, newly formed and mature bones in the experimental group A compared with the control group. Eventually, a higher number of osteoclasts were observed in the experimental group B.
However, the emergence of newly formed and mature bone was lower than in the experimental group A.
The current results suggest that treatment with demineralized and particulate autogenous tooth and interleukin-6 is not effective in stimulating bone regeneration during the bone grafting procedure.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Choi DK / 2007 / effect of particulate dentinplaster of Paris combination with/without fibrin glue in the treatment of bone defects around implants / Hosp Dent 19 : 120 ~ 126
Christine G. McFarlane / 1990 / The release of interleukin-1beta, tumor necrosis factor-alpha and i nterferon-gamma by cultured peripheral blood mononuclear cells from patie
E.F. Rossomando / 1990 / Tumour necrosis factor alpha in gingival crevicular fluid as a possible indicator of periodontal disease in humans / Archives of Oral Biology 35 (6)
Ishimi Y / 1990 / IL-6 is produced by osteoblasts and induces bone resorption / J Immunnol 145 : 3297 ~ 3303
J.J. Jandinski / 1991 / Localization of Interleukin-lβ in Human Periodontal Tissue / Journal of Periodontology 62 (1) : 36 ~ 43
Christine G. McFarlane / 1990 / The release of interleukin-1beta, tumor necrosis factor-alpha and i nterferon-gamma by cultured peripheral blood mononuclear cells from patie
E.F. Rossomando / 1990 / Tumour necrosis factor alpha in gingival crevicular fluid as a possible indicator of periodontal disease in humans / Archives of Oral Biology 35 (6)
Ishimi Y / 1990 / IL-6 is produced by osteoblasts and induces bone resorption / J Immunnol 145 : 3297 ~ 3303
J.J. Jandinski / 1991 / Localization of Interleukin-lβ in Human Periodontal Tissue / Journal of Periodontology 62 (1) : 36 ~ 43
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