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자료유형
학술저널
저자정보
저널정보
대한중환자의학회 Acute and Critical Care Acute and Critical Care 제28권 제2호
발행연도
2013.1
수록면
86 - 92 (7page)

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Background: Selenium is an essential trace-element with antioxidant and immunological function. We studied the relationship between blood selenium concentrations, systemic inflammatory response syndrome (SIRS) and organ dysfunctions in critically ill children. Methods: This was a retrospective, observational study of the blood selenium concentrations of critically ill children at the time of a pediatric intensive care unit admission. Results: A total of 62 patients with a median age of 18 (5-180) months were included in this study. The mean of blood selenium concentration (μg/dl) was 8.49 ± 2.42. The platelet count (r = -0.378) and PaCO2 (r = -0.403) showed negative correlations with blood selenium concentration, while PaO2/FiO2 (r = 0.359) and PaO2 (r = 0.355) showed positive correlations (p < 0.05, for all variables). Blood selenium concentrations were significantly lower in patients with SIRS than in those patients without SIRS (8.08 ± 2.42 vs. 9.45 ± 2.02, p = 0.011). Patients with severe sepsis and septic shock had showed significantly lower blood selenium concentrations than those without SIRS (7.03 ± 2.73 vs. 9.45 ± 2.02, p = 0.042). Patients with PaO2/FiO2 ≤ 300 had lower blood selenium concentrations than those with PaO2/FiO2 > 300 (7.90 ± 2.43 vs. 9.54 ± 2.17, p = 0.018). Blood selenium concentrations were significantly lower in patient with PaO2/FiO2 ≤ 200 than in those with PaO2/FiO2 > 300 (7.64 ± 2.76 vs. 9.54 ± 2.17, p = 0.018). Conclusions: Patients with systemic inflammatory response syndrome or respiratory dysfunction showed significantly low blood selenium concentrations.

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