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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.1
- 수록면
- 135 - 141 (7page)
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Anti-proliferation of methanol extract of Curcuma rhizome
on oral squamous cell carcinoma (KB) and osteosarcoma
(HOS) cells were investigated. In order to elucidate the
involvement of telomerase inhibitory activity as a part of
anti-proliferative effect of Curcuma rhizome on cancer cells,
we measured telomerase activity in Curcuma rhizome
extract-treated cancer cells. The concentration inhibited
cell proliferation to 50% (IC50) of the methanol extract of
Curcuma rhizome against oral squamous cell carcinoma
(KB) cells and osteosarcoma (HOS) cells were 21.30 μg/ml
and 39.3 μg/ml, respectively. The methanol extract of
Curcuma rhizome showed inhibitory telomerase inhibitory
effect which is required for cancer cell immortality.
Therefore, it seems that the anticancer effect of methanol
extract of Curcuma rhizome is at least partially due to
telomerase inhibitory effect. Five fraction samples were
prepared according to its polarity differences and analyzed
anti-proliferative effects of each fraction samples on oral
squamous cell carcinoma and osteosarcoma cells. Anticancer
effect was observed in dichloromethane, and ethylacetate
fractions. The highest anticancer effect was found in
dichloromethane fraction which had IC50 value of 23.3 μg/
ml and 10.5 μg/ml against oral squamous cell carcinoma
(KB) cells and osteosarcoma (HOS) cells, respectively.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Akiyama, M / 2002. / Telomerase inhibitors as anticancer therapy. 2 : 567 ~ 575
Allsopp / 1992. / Telomere length predicts replicative capacity of human fibroblasts.Proc. Natl. Acad. Sci. USA 89 : 10114 ~ 10118
Blackburn / 1991. / Structure and function of telomeres. Nature 350 : 569 ~ 573
Giridharan, P / 2002. / Novel substituted methylenedioxy lignan suppresses proliferation of cancer cells by inhibiting telomerase andactivation of c-myc and caspases leading
Kang, S. C / 2006. / Evalution of oriental medicinal herbs for estrogenic and antiproliferative activities. 20 : 1017 ~ 1019
Allsopp / 1992. / Telomere length predicts replicative capacity of human fibroblasts.Proc. Natl. Acad. Sci. USA 89 : 10114 ~ 10118
Blackburn / 1991. / Structure and function of telomeres. Nature 350 : 569 ~ 573
Giridharan, P / 2002. / Novel substituted methylenedioxy lignan suppresses proliferation of cancer cells by inhibiting telomerase andactivation of c-myc and caspases leading
Kang, S. C / 2006. / Evalution of oriental medicinal herbs for estrogenic and antiproliferative activities. 20 : 1017 ~ 1019
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