Anticancer Effects of Curcuma C20-Dialdehyde against Colon and Cervical Cancer Cell Lines

Chaithongyot, Supattra; Asgar, Ali; Senawong, Gulsiri; Yowapuy, Anongnat; Lattmann, Eric; Sattayasai, Nison; Senawong, Thanaset

추천

검색

자료유형: 학술저널

저자정보: Chaithongyot, Supattra (Department of Biochemistry, Faculty of Science, Khon Kaen University) Asgar, Ali (Program in Biological Science, Faculty of Science, Khon Kaen University) Senawong, Gulsiri (Department of Biochemistry, Faculty of Science, Khon Kaen University) Yowapuy, Anongnat (Department of Biochemistry, Faculty of Science, Khon Kaen University) Lattmann, Eric (Division of Pharmacy, School of Life and Health Sciences, Aston University) Sattayasai, Nison (Department of Biochemistry, Faculty of Science, Khon Kaen University) Senawong, Thanaset (Department of Biochemistry, Faculty of Science, Khon Kaen University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제15호

발행연도: 2015.1

수록면: 6,513 - 6,519 (7page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Background: Recent attention on chemotherapeutic intervention against cancer has been focused on discovering and developing phytochemicals as anticancer agents with improved efficacy, low drug resistance and toxicity, low cost and limited adverse side effects. In this study, we investigated the effects of Curcuma C20-dialdehyde on growth, apoptosis and cell cycle arrest in colon and cervical cancer cell lines. Materials and Methods: Antiproliferative, apoptosis induction, and cell cycle arrest activities of Curcuma C20-dialdehyde were determined by WST cell proliferation assay, flow cytometric Alexa fluor 488-annexin V/propidium iodide (PI) staining and PI staining, respectively. Results: Curcuma C20 dialdehyde suppressed the proliferation of HCT116, HT29 and HeLa cells, with IC50 values of $65.4{\pm}1.74{\mu}g/ml$, $58.4{\pm}5.20{\mu}g/ml$ and $72.0{\pm}0.03{\mu}g/ml$, respectively, with 72 h exposure. Flow cytometric analysis revealed that percentages of early apoptotic cells increased in a dose-dependent manner upon exposure to Curcuma C20-dialdehyde. Furthermore, exposure to lower concentrations of this compound significantly induced cell cycle arrest at G1 phase for both HCT116 and HT29 cells, while higher concentrations increased sub-G1 populations. However, the concentrations used in this study could not induce cell cycle arrest but rather induced apoptotic cell death in HeLa cells. Conclusions: Our findings suggest that the phytochemical Curcuma C20-dialdehyde may be a potential antineoplastic agent for colon and cervical cancer chemotherapy and/or chemoprevention. Further studies are needed to characterize the drug target or mode of action of the Curcuma C20-dialdehyde as an anticancer agent.

#Antiproliferative activity #apoptosis #cervical #Curcuma C20-dialdehyde #cell cycle arrest #colon cancer

참고문헌 (0)

참고문헌 신청

참고문헌이 DBpia에서 서비스 중이라면, [참고문헌 신청]을 통해 등록해보세요

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!