지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 73 - 79 (7page)
이용수
초록· 키워드
오류제보하기
Cytosolic Ca 2+ is an important regulator of tumor cell proliferation and metastasis. Recently, the strategy of blocking receptors and channels specific to certain cancer cell types has emerged as a potentially viable future treatment. Oral squamous cell carcinoma is an aggressive form of cancer with a high metastasis rate but the receptormechanisms involved in Ca 2+ signaling in these tumors have not yet been elucidated. In our present study, we report that bradykinin induces Ca 2+ signaling and its modulation in the human oral squamous carcinoma cell line, HSC-3.
Bradykinin was found to increase the cytosolic Ca 2+ levels in a concentration-dependent manner. This increase was inhibited by pretreatment with the phospholipase C-β inhibitor, U73122, and also by 2-aminoethoxydiphenyl borate, an inhibitor of the inositol 1,4,5-trisphosphate receptor. Pretreatment with extracellular ATP also inhibited the peak bradykinin-induced Ca 2+ rise. In contrast, the ATP-induced rise in cytosolic Ca 2+ was not affected by pretreatment with bradykinin. Pretreatment of the cells with either forskolin or phorbol 12-myristate 13-acetate (activators of adenylyl cyclase and protein kinase C, respectively) prior to bradykinin application accelerated the recovery of cytosolic Ca 2+ to baseline levels. These data suggest that bradykinin receptors are functional in Ca 2+ signaling in HSC-3 cells and may therefore represent a future target in treatment strategies for human oral squamous cell carcinoma.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Barki-Harrington L / 2003 / Requirement for direct cross-talk between B1 and B2 kinin receptors for the proliferation of androgen-insensitive prostate cancer PC3 cells / Bioc
Bhoola KD / 1992 / Bioregulation of kinins: kallikreins, kininogens, and kininases / Pharmacol Rev 44 : 1 ~ 80
Chan DC / 2002 / Bradykinin antagonist dimer, CU201, inhibits the growth of human lung cancer cell lines in vitro and in vivo and produces synergistic growth inhibition in co
Choi SY / 2001 / Potentiation of PGE2-mediated cAMP production during neuronal differentiation of human neuroblastoma SK-N-BE(2)C cells / J Neurochem 79 : 303 ~ 310
Chuang HH / 2001 / Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5) P2-mediated inhibition / Nature 411 : 957 ~ 962
Bhoola KD / 1992 / Bioregulation of kinins: kallikreins, kininogens, and kininases / Pharmacol Rev 44 : 1 ~ 80
Chan DC / 2002 / Bradykinin antagonist dimer, CU201, inhibits the growth of human lung cancer cell lines in vitro and in vivo and produces synergistic growth inhibition in co
Choi SY / 2001 / Potentiation of PGE2-mediated cAMP production during neuronal differentiation of human neuroblastoma SK-N-BE(2)C cells / J Neurochem 79 : 303 ~ 310
Chuang HH / 2001 / Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5) P2-mediated inhibition / Nature 411 : 957 ~ 962
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Contractile and Electrical Responses of Guinea-pig Gastric Smooth Muscle to Bradykinin
대한생리학회지
1995 .01
-
생쥐 작은창자 사이질세포에서 bradykinin의 효과 및 bradykinin 수용체 아형의 발현
해부·생물인류학
2004 .12
-
Central Pressor Mechanisms of Bradykinin in 2-Kidney, 1 Clip Goldblatt Hypertensive Rats
대한생리학회지
1992 .01
-
신장 조직의 브라디키닌 결합부위 발현
약학회지
1994 .01
-
Liquid phase combinatorial synthesis of non-peptide bradykinin antagonists and evaluation of their activity on guinea-pig ileum
대한약학회 학술대회
2003 .01
-
Bradykinin-Mediated Stimulation of Phospholipase D in Rabbit Kidney Proximal Tubule Cells
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
1994 .01
-
Developing a pharmacophore model for nonpeptide bradykinin antagonists
대한약학회 학술대회
2003 .01
-
Depolarizing Effectors of Bradykinin Signaling in Nociceptor Excitation in Pain Perception
Biomolecules & Therapeutics(구 응용약물학회지)
2018 .01
-
The 3D-QSAR study of non-peptide bradykinin antagonists by CoMFA
대한약학회 학술대회
2003 .01
-
Histamine Signaling Pathway in Sensory Neurons is Similar to Bradykinin
대한약학회 학술대회
2003 .01
-
Mustard Oil에 의한 자궁 감각 신경 섬유의 Bradykinin민감도에 대한 NK-1 수용체 차단제의 효과
Obstetrics & Gynecology Science
2003 .01
-
골아세포내 $Ca^{2+}$ 활성도의 조절기전
기초간호자연과학회지
1999 .01
-
한국인에서 구강 편평세포암종의 5년 생존율
대한구강악안면외과학회지
2009 .01
-
유방의 원발성 편평상피암종의 세침흡인 세포학적 소견 - 1예 보고 -
대한세포병리학회지
1996 .01
-
전이성 편평 세포암종의 체액 세포학적 소견
대한세포병리학회지
1992 .01
-
Prognostic Value of Preoperative Serum CA 242 in Esophageal Squamous Cell Carcinoma Cases
Asian Pacific journal of cancer prevention : APJCP
2013 .01
-
Primary Squamous Cell Carcinoma of the Liver
한국간담췌외과학회 학술대회지
2012 .04
-
Methanol extracts of Fructus Psoraleae inhibit bradykinin-mediated pain reactions
대한약학회 학술대회
2000 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0