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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.1
- 수록면
- 79 - 84 (6page)
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초록· 키워드
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Oral squamous carcinoma (OSC) is the most common malignant neoplasm of the oral mucosa. Although the
etiology of OSC is not fully understood, accumulated evidences
indicate that the activation of proto-oncogenes and the
inactivation of tumor suppressor genes underlie the disease
development. An OSC cell line, YD-9 was newly established and characterized. However, the mutational analysis of p53
gene was not performed. Thus, in this study, the presence of
mutation in the p53 gene was examined by amplification of
exon-4 to -8 and subsequent DNA sequencing. Two point mutations were found in exon-4 and -6: A to G, resulting in amino acid change Tyr to Cys in exon-4, and C to G, resulting in amino acid change Gly to Arg in exon-6, respectively. Any
mutation was not found in the exon-5, -7 and -8. The presented
results would contribute to basic research to understand the
biological mechanism of OSC using YD-9 cells.
목차
등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
A / 1989. / High incidence of lung and lymphoid tumors in transgenic mice overexpressing mutant alleles of the p53 oncogene. Mol.. Cell Biol. 9 : 3982 ~ 3991
B / 1987. / Deletion of 5'-coding sequences of 84 Ji-Hak Min and Gyoo-Cheon Kimthe celular p53 gene in mouse erythroleukemia a novel mechanism of oncogene regulation. Mol. C
D / 1984. / Participation of p53 celular tumour antigen in transformation of normal embryonic cells. Nature 312 gi : 646 ~ 649
D.M / 1981. / Ten human carcinoma cel lines derived from squamouse carcinomas of the head and neck. Br. J. Cancer 43 : 772 ~ 785
G / 1989. / The cell biology of human papilomavirus transformed cells. Anticancer Res. 9 : 1447 ~ 1456
B / 1987. / Deletion of 5'-coding sequences of 84 Ji-Hak Min and Gyoo-Cheon Kimthe celular p53 gene in mouse erythroleukemia a novel mechanism of oncogene regulation. Mol. C
D / 1984. / Participation of p53 celular tumour antigen in transformation of normal embryonic cells. Nature 312 gi : 646 ~ 649
D.M / 1981. / Ten human carcinoma cel lines derived from squamouse carcinomas of the head and neck. Br. J. Cancer 43 : 772 ~ 785
G / 1989. / The cell biology of human papilomavirus transformed cells. Anticancer Res. 9 : 1447 ~ 1456
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