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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.1
- 수록면
- 45 - 51 (7page)
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초록· 키워드
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R-type (Cav2.3) calcium channel contributes to pain sensation in peripheral sensory neurons. Six isoforms of Cav2.3 that result from combinations of presence or deletion of three inserts (insert I and insert in the II-III loop, and insert III in N-terminal regions) have been demonstrated to be present in different mammalian tissues. However, the molecular basis of Cav2.3 in trigeminal ganglion (TG) neurons is not known. In the present study, we determined which isoforms of Cav2.3 are expressed in rat TG neurons using the RT-PCR analysis. Whole tissue RT-PCR analyses revealed that only two isoforms, Cav2.3a and Cav2.3e, were present in TG neurons. From single-cell RT-PCR, we found that Cav2.3e rather than Cav2.3a was the major isoform expressed in TG neurons, and Cav2.3e was preferentially detected in small-sized neurons that express nociceptive marker, transient receptor potential vanilloid 1 (TRPV1). Our results suggest that Cav2.3e in trigeminal neurons may be a potential target for the pain treatment.
목차
등록된 정보가 없습니다.
참고문헌 (29)
참고문헌 신청
/ 1992 / Molecular cloning and characterization of a novel calcium channel from rabbit brain : 7 ~ 13
/ 1994 / Identification of calcium channels that control neurosecretion : 828 ~ 266 831
/ 1994 / Messenger plasticity in primary sensory neurons following axotomy and its functional implications : 22 ~ 30
/ 1994 / Molecular analysis and functional expression of the human type E neuronal Ca2+ channel alpha 1 subunit : 255 ~ 270
/ 1994 / Structure and functional characteri-zation of neuronal alpha 1E calcium channel subtypes : 22347 ~ 22357
/ 1994 / Identification of calcium channels that control neurosecretion : 828 ~ 266 831
/ 1994 / Messenger plasticity in primary sensory neurons following axotomy and its functional implications : 22 ~ 30
/ 1994 / Molecular analysis and functional expression of the human type E neuronal Ca2+ channel alpha 1 subunit : 255 ~ 270
/ 1994 / Structure and functional characteri-zation of neuronal alpha 1E calcium channel subtypes : 22347 ~ 22357
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