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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 171 - 174 (4page)
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초록· 키워드
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Background: Inducible MLSB (macrolide-lincosamide-streptogramin B) resistance in staphylococci is not detected by standard susceptibility test methods. Failure to identify inducible MLSB resistance may lead to clinical failure during clindamycin therapy. We determined the prevalence of inducible MLSB resistance in erythromycin-resistant staphylococcal isolates.
Materials and Methods: We evaluated all 2,792 non-duplicate staphylococcal strains: 1,402 Staphylococcus aureus and 1,390 coagulase-negative staphylococci (CoNS) isolated from May 2008-June 2009 at one-unoversity hospital. Testing for inducible MLSB was accomplished by the disk approximation test (D-test) in accordance with the recommendations of the Clinical and Laboratory Standards Institute (CLSI).
Results: Of the 2,792 staphylococcal isolates, 892 S. aureus isolates and 740 CoNS isolates were resistant to erythromycin. Among the 892 erythromycin-resistant S.
aureus isolates, the overall prevalence of inducible MLSB was 21.3% (16.2% of MRSA and 76.3% of methicillin-susceptible S. aureus). Among the 740 erythromycinresistant CoNS isolates, the overall prevalence of inducible MLSB was 16.5% (16.0%of methicillin-resistant CoNS and 18.7% of methicillin-susceptible CoNS). The D-test was positive in 88.8% of S. aureus and 28.4% of CoNS isolates, which were erythromycin-resistant and clindamycin-susceptible.
Conclusions: There are some variations in the prevalence of inducible MLSB resistance in clinical staphylococcal isolates. It is important that clinical laboratories report inducible MLSB resistance for erythromycin-resistant and clindamycinsusceptible staphylococcal isolates.
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참고문헌 (21)
참고문헌 신청
[학술지(
Aktas Z / 2007 / Resistance to macrolide, lincosamide and streptogramin antibiotics in staphylococci isolated in Istanbul, Turkey / J Microbiol 45 : 286 ~ 290
Bemer P / 2005 / Correlation of agar dilution and VITEK2 system for detection of resistance to macrolides, lincosamides and pristinamycin among Staphylococcus aureus and Sta
Cetin ES / 2008 / Macrolidelincosamide-streptogramin B resistance phenotypes in clinical staphylococcal isolates / Int J Antimicrob Agents 31 : 364 ~ 368
Chavez-Bueno S / 2005 / Inducible clindamycin resistance and molecular epidemiologic trends of pediatric community-acquired methicillin-resistant Staphylococcus aureus in Da
Aktas Z / 2007 / Resistance to macrolide, lincosamide and streptogramin antibiotics in staphylococci isolated in Istanbul, Turkey / J Microbiol 45 : 286 ~ 290
Bemer P / 2005 / Correlation of agar dilution and VITEK2 system for detection of resistance to macrolides, lincosamides and pristinamycin among Staphylococcus aureus and Sta
Cetin ES / 2008 / Macrolidelincosamide-streptogramin B resistance phenotypes in clinical staphylococcal isolates / Int J Antimicrob Agents 31 : 364 ~ 368
Chavez-Bueno S / 2005 / Inducible clindamycin resistance and molecular epidemiologic trends of pediatric community-acquired methicillin-resistant Staphylococcus aureus in Da
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