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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 81 - 85 (5page)
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Background: Dry eye is a common disease. Many patients continue to experience residual symptoms despite opti-mal treatment. Thus, new treatment options are required. The purpose of this study was to evaluate the association between serum 25-hydroxyvitamin D [25(OH)D] levels and dry eye.Methods: This study was performed using data from the fifth Korean National Health and Nutrition Examination Survey, which is a cross-sectional study of the Korean population that was conducted from 2010 to 2011. We in-cluded adults aged >19 years who underwent ophthalmologic interviews and examinations. We excluded subjects who had comorbid conditions (rheumatoid arthritis, thyroid disease, chronic kidney disease, or depression) that are associated with dry eye. The subjects were divided into normal and dry eye groups. The dry eye group consisted of those who had clinically diagnosed dry eye syndrome or symptoms. Multiple logistic regression analysis was conducted to determine the association between serum 25(OH)D levels and dry eye.Results: In the univariate model, the 25(OH)D levels were lower in the dry eye group than in the normal group (P=0.01). A significant association was found between severe vitamin D deficiency (<10 ng/mL) and dry eye (P=0.04). However, after multivariate adjustment, the statistical significance of the association disappeared (P-val-ues=0.49, vitamin D insufficiency; P=0.33, vitamin D deficiency; P=0.18, severe vitamin D deficiency).Conclusion: Severe vitamin D deficiency was associated with dry eye in an unadjusted model, but the association was not statistically significant after adjustment.
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참고문헌 (21)
참고문헌 신청
Adams JS / 2010 / Update in vitamin D / J Clin Endocrinol Metab 95 : 471 ~ 478
Dawson-Hughes B / 2005 / Estimates of optimal vitamin D status / Osteoporos Int 16 : 713 ~ 716
Definition and Classification Subcommittee of the International Dry Eye WorkShop / 2007 / The definition and classification of dry eye disease : report of the Definition and
Drouault-Holowacz S / 2009 / Antioxidants intake and dry eye syndrome: a crossover, placebo-controlled, randomized trial / Eur J Ophthalmol 19 : 337 ~ 342
Galor A / 2014 / Effect of a Mediterranean dietary pattern and vitamin D levels on Dry Eye syndrome / Cornea 33 : 437 ~ 441
Dawson-Hughes B / 2005 / Estimates of optimal vitamin D status / Osteoporos Int 16 : 713 ~ 716
Definition and Classification Subcommittee of the International Dry Eye WorkShop / 2007 / The definition and classification of dry eye disease : report of the Definition and
Drouault-Holowacz S / 2009 / Antioxidants intake and dry eye syndrome: a crossover, placebo-controlled, randomized trial / Eur J Ophthalmol 19 : 337 ~ 342
Galor A / 2014 / Effect of a Mediterranean dietary pattern and vitamin D levels on Dry Eye syndrome / Cornea 33 : 437 ~ 441
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