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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 283 - 291 (9page)
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Vaccine is one of the best known and most successful applications of immunological theory to human health and it protects human life through inducing the immune response in systemic compartment. However, when we consider the fact that mucosal epithelium is exposed to diverse foreign materials including viruses, bacteria, and food antigens and protects body from entry of unwanted materials using layer of tightly joined epithelial cells,establishing the immunological barrier on the lining of mucosal surfaces is believed to be an effective strategy to protect body from unwanted antigens. Unfortunately, however, oral mucosal site, which is considered as the best target to induce mucosal immune response due to application convenience, is prone to induce immune tolerance rather than immune stimulation. Since intestinal epithelium is tightly organized, a prerequisite for successful mucosal vaccination is delivery of antigen to mucosal immune induction site including a complex system of highly specialized cells such as M cells. Consequently, development of efficient mucosal adjuvant capable of introducing antigens to mucosal immune induction site and overcome oral tolerance is an important subject in oral vaccine development. In this review, various approaches on the development of oral mucosal adjuvants being suggested for effective oral mucosal immune induction.
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참고문헌 (28)
참고문헌 신청
[학술
Abreu MT / 2010 / Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function / Nat Rev Immunol 10 : 131 ~ 144
Bevan MJ / 2004 / Helping the CD8 (+) T-cell response / Nat Rev Immunol 4 : 595 ~ 602
Blanco HM / 2008 / IgA response by oral infection with an attenuated Yersinia enterocolitica mutant: implications for its use as oral carrier vaccine / Vaccine 26 : 6497 ~ 65
Brandtzaeg P / 2005 / Mucosal B cells: phenotypic characteristics, transcriptional regulation, and homing properties / Immunol Rev 206 : 32 ~ 63
Abreu MT / 2010 / Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function / Nat Rev Immunol 10 : 131 ~ 144
Bevan MJ / 2004 / Helping the CD8 (+) T-cell response / Nat Rev Immunol 4 : 595 ~ 602
Blanco HM / 2008 / IgA response by oral infection with an attenuated Yersinia enterocolitica mutant: implications for its use as oral carrier vaccine / Vaccine 26 : 6497 ~ 65
Brandtzaeg P / 2005 / Mucosal B cells: phenotypic characteristics, transcriptional regulation, and homing properties / Immunol Rev 206 : 32 ~ 63
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