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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 288 - 292 (5page)
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초록· 키워드
오류제보하기
Cisplatin is a platinum-based chemotherapeutic drug for treating various types of cancers. However, the use of cisplatin is limited by its negative effect on normal tissues, particularly nephrotoxicity. Various mechanisms such as DNA adduct formation, mitochondrial dysfunction, oxidative stress, and apoptosis are involved in the adverse effect induced by cisplatin treatment. Several studies have suggested that neuropeptide Y (NPY) is involved in neuroprotection as well as restoration of bone marrow dysfunction from chemotherapy induced nerve injury. However, the role of NPY in chemotherapy- induced nephrotoxicity has not been studied. Here, we show that NPY rescues renal dysfunction by reducing the expression of pro-apoptotic proteins in cisplatin induced nephrotoxicity through Y1 receptor, suggesting that NPY can protect kidney against cisplatin nephrotoxicity as a possible useful agent to prevent and treat cisplatin-induced nephrotoxicity.
목차
등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Pabla N / 2008 / Cisplatin nephrotoxicity: mechanisms and renoprotective strategies / Kidney Int 73:994~1007
Siddik ZH / 2003 / Cisplatin : mode of cytotoxic action, molecular basis of resistance / Oncogene 22:7265~7279
Pabla N / 2011 / Inhibition of PKCreduces cisplatin-induced nephrotoxicity without blocking chemotherapeutic efficacy in mouse models of cancer / J Clin Invest 121:2709~2722
Jia Z / 2011 / Amelioration of cisplatin nephrotoxicity by genetic or pharmacologic blockade of prostaglandin synthesis / Kidney Int 79:77~88
Oh GS / 2014 / Pharmacological activation of NQO1 increases NAD＋ levels, attenuates cisplatin-mediated acute kidney injury in mice / Kidney Int 85:547~560
Siddik ZH / 2003 / Cisplatin : mode of cytotoxic action, molecular basis of resistance / Oncogene 22:7265~7279
Pabla N / 2011 / Inhibition of PKCreduces cisplatin-induced nephrotoxicity without blocking chemotherapeutic efficacy in mouse models of cancer / J Clin Invest 121:2709~2722
Jia Z / 2011 / Amelioration of cisplatin nephrotoxicity by genetic or pharmacologic blockade of prostaglandin synthesis / Kidney Int 79:77~88
Oh GS / 2014 / Pharmacological activation of NQO1 increases NAD＋ levels, attenuates cisplatin-mediated acute kidney injury in mice / Kidney Int 85:547~560
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