지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 454 - 460 (7page)
이용수
초록· 키워드
오류제보하기
Naturally occurring reoviruses are live replication-proficient viruses that specifically infect human cancer cells while sparing their normal counterpart. Since the discovery of reoviruses in 1950s, they have shown various degrees of safety and efficacy in pre-clinical or clinical applications for human anti-cancer therapeutics. I have recently discovered that cellular tumor suppressor genes are also important in determining reoviral tropism. Carcinogenesis is a multi-step process involving the accumulation of both oncogene and tumor suppressor gene abnormalities. Reoviruses can exploit abnormal cellular tumor suppressor signaling for their oncolytic specificity and efficacy.
Many tumor suppressor genes such as p53, ataxia telangiectasia mutated (ATM), and retinoblastoma associated (RB) are known to play important roles in genomic fidelity/maintenance. Thus, a tumor suppressor gene abnormality could affect host genomic integrity and likely disrupt intact antiviral networks due to the accumulation of genetic defects which in turn could result in oncolytic reovirus susceptibility. This review outlines the discovery of oncolytic reovirus strains, recent progresses in elucidating the molecular connection between oncogene/tumor suppressor gene abnormalities and reoviral oncotropism, and their clinical implications. Future directions in the utility of reovirus virotherapy is also proposed in this review.
목차
등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Bennette JG / 1960 / Isolation of a Non-pathogenic Tumour-destroying Virus from Mouse Ascites / Nature 187 : 72 ~ 73
Bennette JG / 1967 / Characteristics of a newborn runt disease induced by neonatal infection with an oncolytic strain of reovirus type 3(REO3MH). I. Pathological investigati
Coffey MC / 1998 / Reovirus therapy of tumors with activated Ras pathway / Science 282 : 1332 ~ 1334
Duncan MR / 1978 / Differential sensitivity of normal and transformed human cells to reovirus infection / J Virol 28 : 444 ~ 449
Hashiro G / 1977 / The preferential cytotoxicity of reovirus for certain transformed cell lines / Arch Virol 54 : 307 ~ 315
Bennette JG / 1967 / Characteristics of a newborn runt disease induced by neonatal infection with an oncolytic strain of reovirus type 3(REO3MH). I. Pathological investigati
Coffey MC / 1998 / Reovirus therapy of tumors with activated Ras pathway / Science 282 : 1332 ~ 1334
Duncan MR / 1978 / Differential sensitivity of normal and transformed human cells to reovirus infection / J Virol 28 : 444 ~ 449
Hashiro G / 1977 / The preferential cytotoxicity of reovirus for certain transformed cell lines / Arch Virol 54 : 307 ~ 315
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
총기 소음기에 적용된 기술과 소재에 대한 동향 및 전망
한국기계기술학회지
2024 .08
-
P42 Ebp1 functions as a tumor suppressor in non-small cell lung cancer
BMB Reports
2015 .01
-
Therapeutic Microspheres with Oncolytic Bacteria for the Treatment of Tumors
한국생물공학회 학술대회
2022 .09
-
Novel Oncolytic Virus Engineering for Improved Antitumor Activity
한국생물공학회 학술대회
2020 .10
-
Aurora kinase A, a synthetic lethal target for precision cancer medicine
Experimental and Molecular Medicine
2021 .05
-
Cancer-favoring oncolytic vaccinia virus and anti-PD1-based combination therapy for cancer
한국생물공학회 학술대회
2017 .10
-
Superenhancers as master gene regulators and novel therapeutic targets in brain tumors
Experimental and Molecular Medicine
2023 .02
-
Potential of synthetic peptides in polymeric gene carrier : Enhanced endosomal escape, anti-tumor, and tumor-targeting effects
한국생물공학회 학술대회
2016 .04
-
Rebuilding the microenvironment of primary tumors in humans: a focus on stroma
Experimental and Molecular Medicine
2024 .03
-
Interactions between tumor-derived proteins and Toll-like receptors
Experimental and Molecular Medicine
2020 .12
-
형태학적 연산과 뇌종양 평균 크기를 이용한 감마나이프 치료 범위 자동 검출 알고리
멀티미디어학회논문지
2015 .10
-
Polylactic Acid-based Multifunctional Porous Microspheres Loaded with Oncolytic Spores for Imaging-guided Cancer Therapy
한국고분자학회 학술대회 연구논문 초록집
2024 .09
-
ER membrane protein complex subunit 6 (EMC6) is a novel tumor suppressor in gastric cancer
BMB Reports
2017 .01
-
Polylactic Acid-based Multifuctional Porous Microspheres Loaded with Oncolytic bacteria for Targeted Cancer Therapy
한국고분자학회 학술대회 연구논문 초록집
2023 .10
-
Engineering of tumor microenvironment on a chip for evaluating combination immunotherapy
대한기계학회 춘추학술대회
2021 .04
-
Effect of chromatin modifiers on the plasticity and immunogenicity of small-cell lung cancer
Experimental and Molecular Medicine
2022 .12
-
Engineering of vascularized 3D cancer on a chip modeling for drug delivery
대한기계학회 춘추학술대회
2021 .04
-
A review on three dimensional scaffolds for tumor engineering
Biomaterials and Biomechanics in Bioengineering
2016 .01
-
Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways
Experimental and Molecular Medicine
2018 .01
-
Development of Tumor Microenvironment-Modulating Nanoparticles for Improved Anti-Tumor Efficacy of Immunotherapy
한국고분자학회 학술대회 연구논문 초록집
2022 .04
이 논문의 저자 정보
최근 본 자료
댓글(0)
0